甘肃人群NQO1基因多态性与急性髓系白血病易感性的关系  

Relationship between NQO1 gene polymorphisms and susceptibility of acute myeloid leukemia in Gansu population

作　　者：徐建旺[1] 石秀娥[2] 贾明峰[1] 李明[1] 张豪[1] 李蓓[1] 刘春霞[1] 姚小健[1] 马海珍[1] 席亚明[1] 

机构地区：[1]兰州大学第一医院血液科血液学研究所,兰州730000 [2]甘肃省康复中心医院老年病科

出　　处：《临床血液学杂志（输血与检验）》2010年第6期718-720,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

基　　金：甘肃人群毒物代谢酶基因的遗传多态性与白血病易感性的相关研究(No:0708NKCA113)

摘　　要：目的:研究醌氧化还原酶(NQO1)基因多态性和急性髓系白血病易感性的关系。方法:用1:1配对病例-对照方法,PCR-LDR方法,对78例急性髓系白血病患者(AML)和100例对照人群进行NQO1基因突变分析。结果:AML病例组NQO1基因T等位基因频率(43%)和TC/TT基因型频率(63%)均高于对照组(28%和43%)。携带TC/TT基因型的个体发生AML的相对风险度为其野生型(CC)的1.67倍(95%CI=1.212～2.727)。结论:NQO1基因多态性与AML遗传易感性相关,等位基因C对AML易感性有保护作用。Objective：To explore the relationship between quinone oxidoreductase 1（NQO1）gene polymorphisms and the susceptibility of the acute myeloid leukemia in Gansu population.Method：The C609 Tpolymorphism of NQO1 gene was investigated by polymerase chain reaction-ligase detection reaction（PCR-LDR）in 100 normal people（control group）and 78 people with acute myeloid leukemia（AML group）.Result：The T allele genotype and TC/TT genotype of NQO1gene occurred more frequently in AML group（43% and 63%）than those in control group（28% and 43%）（P〈0.05）.The people with TC/TT genetype had increased 1.67-fold AML risk,compared with the individual with CC genotype（95% CI=1.212～2.727）.Conclusion：NQO1 gene polymorphism was associated with the susceptibility of acute myeloid leukemia in Gansu population.The risk of AML was increased in the persons carrying allele T.

关 键 词：醌氧化还原酶(NQO1) 基因多态性 易感性 急性髓系白血病 

分 类 号：R457.1[医药卫生—治疗学]