癌痛消颗粒对大鼠移植性肝癌VEGF-C的干预作用  

Intervention of Aitongxiao Granule on VEGF-C in Rat Transplantation Tumor Model of Liver Cancer

作　　者：韦艾凌[1] 邱子津[2] 陆海颂[2] 

机构地区：[1]广西中医学院第一附属医院,广西南宁530023 [2]广西中医学院第一临床医学院,硕士研究生广西南宁530023

出　　处：《湖北中医学院学报》2010年第6期14-16,共3页Journal of Hubei College of Traditional Chinese Medicine

基　　金：广西科学研究与技术开发项目(桂研攻0718002-2-15);广西自然科学基金课题资助(桂科计字(2009)91号-161)

摘　　要：目的观察癌痛消颗粒对大鼠移植性肝癌血管内皮因子C(VEGF-C)表达的影响。方法将40只大鼠移植性肝癌模型随机分为4组,即癌痛消颗粒高剂量组(A组)、癌痛消颗粒低剂量组(B组)、5-Fu组(C组)、模型对照组(D组),并设正常对照组(E组)。于造模后第8天开始给药,连续用药14d后停药24h,处死大鼠,取出瘤块,测量体积、免疫组化法检测瘤块中VEGF-C的表达情况。结果 A、B、C、D组VEGF-C均高于E组,差异均有统计学意义(均P<0.05),其中以D组VEGF-C表达最高。A、B、C组VEGF-C均低于D组,差异均有统计学意义(均P<0.05)。A组VEGF-C低于B组,差异有统计学意义(P<0.05)。结论癌痛消颗粒对大鼠移植性肝癌VEGF-C的表达有抑制作用,且以高剂量组作用更为明显。Objective To observe the influences of Aitongxiao Granule on VEGF-C in rat model of liver cancer via transplantation of tumor.Methods 40 modeled rats were randomized into 4 groups： Aitongxiao granule high dose treatment group（group A）,low dose group（group B）,5-Fu group（group C）,normal saline treatment group（group D）.Groups A,B,D were given medication by gastric perfusion,group C by intraperitoneal injection.Rats were sacrificed for sampling tumor tissue for detecting VEGF-C expression after 14 days consecutive treatment followed by 24 hours rest.Another 10 rats,without modeling and treatment,made up group E for control at the end of the experiment.Results VEGF-C expressions in groups A,B,C,D were higher than that in normal group（P0.05）,among which the highest was observed in group D（P0.05）.Group A was lower in VEGF-C expression than that in group B（P0.05）.Conclusion Aitongxiao ganule could intervene the expression of VEGF-C with positive dose-dependent effect.

关 键 词：癌痛消颗粒 VEGF-C 大鼠移植性肝癌 

分 类 号：R285.5[医药卫生—中药学]