环氧化酶-2基因启动子区-765G/C多态性与糖尿病视网膜病变的相关性研究  

A study of the association of COX-2 gene promoter region-765G/C polymorphism with diabetic retinopathy

作　　者：周晰溪[1] 宋滇平[1] 

机构地区：[1]昆明医学院第一附属医院糖尿病科,650032

出　　处：《中华临床医师杂志（电子版）》2010年第11期91-93,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：昆明医学院研究生创新基金(KM2008L52)

摘　　要：目的探讨环氧化酶-2(COX-2)基因启动子区-765G/C多态性与糖尿病视网膜病变(DR)的相关性。方法采用聚合酶链反应-限制性片段长度多态性方法,在中国昆明地区汉族人群中,对121例2型糖尿病变伴视网膜病变者(DR),44例2型糖尿病非视网膜病变者,100例健康对照者的COX-2基因-765G/C多态性进行检测;比较分析各组间基因型频率、等位基因频率及相关临床资料。结果 (1)各组间的基因型频率和等位基因频率无统计学意义。(2)糖尿病病程、糖化血红蛋白(HbA1c)%水平是糖尿病视网膜病变发生的危险因素。结论昆明地区汉族人群中,COX-2基因-765G/C多态性与DR无相关关系;糖尿病病程和HbA1c%水平影响2型糖尿病患者DR的发生。Objective To investigate the relationship between the cyclooxygenase2 （ COX-2） gene-765G/C polymorphism and diabetic retinopathy （ DR） in type 2 diabetes mellitus （ T2DM）. Methods -765G/C polymorphism was screened in 121 T2DM patients with DR,44 free-DR T2DM patients and 100 normal controls by PCR-RFLP. The genotypes and allele frequencies distributions were compared among groups,at the same time,the related characteristics of objects were compared. Results （ 1） No significant differences were observed in genotype and allele frequencies distributions of -765G/C polymorphism among all groups. （ 2） A Logistic regression analysis indicated that diabetic duration and HbA1c% were risk factors of DR. Conclusions COX-2 gene -765G/C polymorphism was not significantly associated with DR in Kunming Han people; In T2DM patients,diabetic duration and HbA1c% may contribute to DR.

关 键 词：糖尿病 2 型 糖尿病视网膜病变 环氧化酶2 多态性 单核苷酸 

分 类 号：R587.2[医药卫生—内分泌]