复方丹参片对糖尿病大鼠山梨醇代谢通路的影响  

The effects of compound red-rooted salvia on metabolism of polyol in diabetic rats

作　　者：杨美玲[1] 穆景阳 卢华爱[1] 高兰月[1] 杨桂珍[1] 

机构地区：[1]宁夏医科大学,宁夏银川750004 [2]宁夏医科大附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2010年第12期1099-1101,共3页Ningxia Medical Journal

基　　金：宁夏自治区卫生厅重点科研计划资助项目(W2006010)

摘　　要：目的观察复方丹参对链脲佐菌素(STZ)糖尿病大鼠心肌、红细胞多元醇代谢通路的影响。方法动物以灌胃给药,连续4周,观察药物对链脲佐菌素糖尿病大鼠血糖(FBG)、体重(W)、超氧化物岐化酶(SOD)活性、丙二醛(MDA)及坐骨神经山梨醇、红细胞山梨醇(RBCS)含量的变化,并测定坐骨神经传导速度。结果复方丹参能降低糖尿病大鼠MDA(P<0.05)和坐骨神经山梨醇、红细胞山梨醇含量(P<0.05),升高SOD水平(P<0.05),并能增加坐骨神经传导速度。结论复方丹参对STZ实验性糖尿病鼠体内多元醇代谢功能增强有抑制作用。Objective To observe the effect of compound red-rooted salvia on polyol metabolic pathway in myocardium and erythrocyte on STZ-induced diabetic rats.Methods Compound red-rooted salvia was administrated intra-gastrically for 4 weeks to observe the effect of compound red-rooted salvia on FBG,BW,SOD,MDA and RBCS level and monitor the conduction velocity of sciatic nerve.Results Compound red-rooted salvia reduced MDA and RBCS level in nerve and erythrocyte and increase SOD and conduction velocity of sciatic verve.Conclusion Compound red-rooted salvia can inhibit the over activity of metabolic function of polyol in the STZ-induced diabetic rats.

关 键 词：复方丹参 糖尿病 多元醇代谢 

分 类 号：R285[医药卫生—中药学]