宫内生长迟缓儿脐血内脂素与胰岛素水平关系研究  

Relationship between Cord Blood Visfatin and Insulin in Intrauterine Growth Retardation

作　　者：陈洁如[1] 刘倩琦[2] 

机构地区：[1]南京医科大学附属无锡第二医院儿科,江苏省无锡市214002 [2]南京医科大学附属南京儿童医院内分泌科

出　　处：《中国全科医学》2010年第35期3981-3983,共3页Chinese General Practice

基　　金：无锡市科技局指导性项目(CSZ00914)

摘　　要：目的探讨宫内生长迟缓(IUGR)儿脐血内脂素与胰岛素水平的关系。方法选择足月出生的IUGR儿、巨大儿及正常儿各30例,采用双抗体夹心酶联免疫吸附试验(Elisa)法测定脐血内脂素水平,放射免疫法测定胰岛素水平,分析脐血内脂素、胰岛素水平与出生体质量的关系及脐血内脂素水平与胰岛素水平的关系。结果三组脐血内脂素和胰岛素水平比较,差异均有统计学意义(P<0.05);其中IUGR组脐血内脂素水平较巨大儿组和正常组均明显升高,差异有统计学意义(P<0.05);IUGR组脐血胰岛素水平较巨大儿组和正常组均明显降低,差异有统计学意义(P<0.05)。出生体质量与脐血内脂素水平呈负相关(r=-0.416,P<0.05);出生体质量与脐血胰岛素水平呈正相关性(r=0.341,P<0.05)。脐血内脂素水平与脐血胰岛素水平无相关性(r=-0.164,P>0.05)。结论 IUGR与内脂素、胰岛素等内分泌激素有关,它们通过调节代谢而影响胎儿宫内的生长发育。Objective To investigate the relationship between cord blood visfatin and insulin in intrauterine growth retardation（IUGR）.Methods Ninety full-term birth neonates were divided into groups IUGR,macrosomia and normal,30 in each.Level of cord blood visfatin was determined by double antibody sandwich enzyme-linked immunosorbent assay（Elisa）,insulin level by radioimmunoassay.The relationship of cord blood visfatin,insulin levels to birth weight and relationship between levels of visfatin and insulin were analyzed.Results There was significant difference in visfatin and insulin between 3 groups（P〈0.05）,thereinto cord blood visfatin level was significantly higher in IUGR group than in groups macrosomia and normal（P〈0.05）,but insulin lower（P〈0.05）.Birth weight was negatively correlated to visfatin level（r=-0.416,P〈0.05）,positively to insulin level（r=0.341,P〈0.05）.There was not correlation between cord blood visfatin and insulin（r=-0.164,P〈0.05）.Conclusion IUGR is related to endocrine hormones such as visfatin and insulin,which affect fetal growth and development by regulating metabolism.

关 键 词：胎儿生长迟缓 胎血 内脂素 胰岛素 

分 类 号：R722.1[医药卫生—儿科]