β_3-肾上腺素受体基因多态性与冠心病支架植入术后再狭窄相关性研究  

Relationship between β_3-adrenergic Trp64Arg Mutation and Instent Restenosis after CHD Stenting

作　　者：陈艺钊[1] 李浪[1] 曲楠[1] 黎东华[1] 

机构地区：[1]广西医科大学第一附属医院心内科,广西壮族自治区南宁市530021

出　　处：《中国全科医学》2010年第35期3984-3987,共4页Chinese General Practice

摘　　要：目的探讨β3-肾上腺素受体基因多态性与冠心病支架植入术(PCI)后支架内再狭窄的相关性。方法 2003—2009年我院冠心病PCI术后患者经造影复查证实支架内再狭窄者(再狭窄组)41例,再选取经造影复查无支架内再狭窄者(非再狭窄组)50例,采用聚合酶链反应-限制片段长度多态性技术对β3-肾上腺素受体基因Trp64Arg多态性位点基因型进行检测,比较两组患者基因型分布及等位基因有无差异。结果非再狭窄组患者基因型分布及等位基因频率与再狭窄组比较,差异均无统计学意义(P>0.05),多因素Logistic回归分析显示PCI术后冠状动脉再狭窄与高密度脂蛋白胆固醇(HDL-C)的偏回归系数为-1.452(P<0.05),相对危险度为0.234〔95%可信区间(0.06,0.99)〕。结论β3-肾上腺素受体基因多态性与冠心病PCI术后支架内再狭窄无关,HDL-C是冠状动脉再狭窄的独立保护因素。Objective To investigate the relationship between β3-adrenergic receptor（β3-AR）gene polymorphisms and Instent Restenosis（ISR）after CHD Stenting.Methods A total of 41 patients with restenosis confirmed by radiography and 50 patients free from restenosis were performed polymerase chain reaction-restriction fragment length polymorphism（PCR/RFLP）to detect genotype of the Trp64Arg.The distribution of genotype and allele were compared between the two groups.Results The distribution of the genotypes of β3-AR genetic variants were not significantly different between the restenosis patients and the patients without restenosis（P〈0.05）.Multi-factor logistic regression analysis showed that partial regression coefficient of high density lipoprotein cholesterol（HDL-C）on restenosis was-1.452（P〈0.05）,and relative risk（RR）was 0.234〔with 95% credibility interval（0.06,0.99）〕.Conclusion β3-AR gene polymorphisms are not associated with instent restenosis after PCI,HDL-C is independent protective factor of restenosis.

关 键 词：支架植入术 冠状动脉再狭窄 基因 突变 受体 肾上腺素能β3 冠状动脉硬化 

分 类 号：R654.33[医药卫生—外科学]