干扰素中和抗体的产生与难治性丙型肝炎的相关性  

Relationship of neutralizing anti-interferon antibodies with refractory hepatitis C

作　　者：张文杰 李朝霞 田淑菊 毛维武 龚晏萱 屈延 

机构地区：[1]甘肃省第二人民医院感染科,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2010年第4期73-75,共3页Journal of Lanzhou University（Medical Sciences）

摘　　要：目的探讨干扰素中和抗体(NA)的产生与难治性丙型肝炎的相关性。方法纳入102例初治慢性丙型肝炎患者,根据治疗效果分为难治性丙型肝炎组和对照组,用酶联免疫吸附法检测治疗前及治疗不同时期血清中的干扰素总抗体,同时应用抗病毒中和生物鉴定法检测干扰素NA。结果 44例难治性丙型肝炎患者中有12例出现干扰素NA阳性,对照组干扰素NA的阳性率明显低于难治性丙型肝炎组(P<0.05)。聚乙二醇化干扰素α-2a和干扰素α-1bNA阳性率差异无统计学意义。结论干扰素NA的产生可能是导致难治性丙型肝炎产生的因素之一。Objective To evaluate the relationship between anti-interferon neutralizing antibodies （NA） with refractory hepatitis C.Methods 102 cases with chronic hepatitis C were divided into refractory hepatitis C group and control group.The total anti-interferonα-1b and NA were detected by enzyme immunl assay and antiviral neutralizing bioassay respectively in sera of 102 cases with chronic hepatitis C before the treatment and in different periods during the treatment with interferonα-1b or pegylation interferonα-2a.Results Of the 44 refractory cases with hepatitis C,12 were positive for NA.The positive rates of NA were significantly higher than that in the group of sustained virological response（P0.05）;there was no statistic difference between the group with interferonα-1b and the group with pegylation interferonα-2a.Conclusion The development of NA may be one of the factors for refractory population in hepatitis C.

关 键 词：干扰素中和抗体 难治性丙型肝炎 慢性丙型肝炎 

分 类 号：R512.6[医药卫生—内科学]