2型糖尿病患者糖耐量正常一级亲属血管内皮功能及黏附因子的研究  

Adhesion molecule level and vascular endothelial function in first degree relatives of type 2 diabetes patients with normal glucose

作　　者：戴武[1,2] 韩晓芳[1,2] 叶山东[3] 刘克梅[1,2] 刘玲[1,2] 叶军[1,2] 曹永红[1,2] 陈燕[3] 

机构地区：[1]安徽医科大学第四临床学院 [2]合肥市第二人民医院内分泌科,安徽合肥230011 [3]安徽医科大学附属省立医院内分泌科,安徽合肥230001

出　　处：《中国现代医学杂志》2010年第21期3286-3288,3292,共4页China Journal of Modern Medicine

基　　金：合肥市科技局立项项目[No:合科合同(卫)字2007(1003)号]

摘　　要：目的观察2型糖尿病患者一级亲属(FDRs)糖耐量正常者血管内皮功能受损及黏附因子活化状况。方法测定39例健康对照、61例FDRs的血管内皮功能、血脂、空腹血糖、血清可溶性血管细胞黏附因子-1(sVCAM-1)及可溶性选择素E(SL-E)水平等,同时测定胰岛素水平,计算胰岛素抵抗指数(HOMA-IR)。结果与正常对照组相比较,FDRs组内皮依赖性血管舒张功能减退,SL-E、sVCAM-1、FINS、HOMA-IR、TC、TG升高,差异均有统计学意义(P<0.05),在FDRs组,EDV与HOMA-IR及TG分别呈负相关,而SL-E、sV-CAM-1与HOMA-IR呈正相关。结论 2型糖尿病(T2DM)患者糖耐量正常的一级亲属存在内皮功能受损、黏附因子活化及胰岛素抵抗(IR),并且内皮功能受损与IR相关。【Objective】 To investigate the vascular endothelial function and the level of adhesion molecule in first degree relatives（FDRs） of type 2 diabetes patients with normal glucose.【Methods】 The anthropometrical parameters,the vascular endothelial function,fasting plasma glucose,serum lipid,insulin and vascular cell adhesion molecule-1（sVCAM-1）,selective-E（SL-E）,were analyzed in 61 nondiabetic FDRs and 39 control subjects.Homeostasis model assessment was applied to assess the status of insulin resistance.【Results】 The levels of SL-E,sVCAM-,FINS,HOMA-IR,TC and TG were significantly elevated in FDRs compared with controls.Multiple stepwise regression showed that EDV was negatively related with HOMA-IR while TG,SL-E andsVCAM-1 were positively related with HOMA-IR.【Conclusion】 There are endothelial dysfunction,activation of adhesion molecule and IR in FDRs,and endothelial dysfunction is positively related with IR.

关 键 词：2型糖尿病 正常糖耐量 一级亲属 血管内皮功能 黏附因子 

分 类 号：R587.1[医药卫生—内分泌]