内脂素与子痫前期代谢异常的相关研究  

Relationship between visfatin and abnormal metabolism in preeclampsia

作　　者：夏泳[1,2] 郑颖[1,2] 郑琳[1,2] 林淑鑫[1,2] 郭超[1,2] 

机构地区：[1]福建医科大学教学医院 [2]福州市第二医院妇产科,福州350007

出　　处：《福建医药杂志》2010年第6期16-18,共3页Fujian Medical Journal

基　　金：福州市科技局基金项目(2008-S-75)

摘　　要：目的检测子痫前期(PE)患者血浆内脂素水平变化,探讨其与子痫前期代谢异常的相关性。方法选取2009年2月至2010年8月在福州市第二医院产科住院的子痫前期患者40例(PE组),其中轻度子痫前期28例,重度子痫前期12例;按照1∶1配对原则选取年龄、孕周相匹配的正常孕妇40例为对照组。检测两组人体参数和糖脂代谢指标;采用ELISA方法检测两组血浆内脂素水平;采用稳态模型评估法(HOMA)评估两组胰岛素抵抗指数(HOMA-IR)。结果 (1)PE组血浆内脂素水平显著高于对照组(P<0.01);与轻度子痫前期相比,重度子痫前期患者升高更为显著(P<0.01);(2)血浆内脂素与孕前BMI、舒张压、空腹胰岛素、HOMA-IR、TG、游离脂肪酸呈正相关(P<0.05或P<0.01),与HDL呈负相关(P<0.05);多元回归分析显示,孕前BMI(β=0.227,P<0.05)、HOMA-IR(β=0.164,P<0.05)为血浆内脂素的独立相关因素。结论 PE患者内脂素水平显著增高,且以重度PE为著;内脂素与子痫前期的发生密切相关。Objective To investigate plasma visfatin levels in pregnant women with preeclampsia and correlation with abnormal carbohydrate and lipid metabolism.Methods Forty pregnant women with preeclampsia,which consisted of 12 severe preeclampsia patients and 28 mild preeclampsia patients,and 40 normal pregnant controls were enrolled.Preeclamptic women and normal controls were carefully matched for maternal age and gestational age.All subjects underwent body measurement including height and weight.BMI and pre-gestational BMI（pre-BMI）were calculated.Peripheral blood samples were collected to detect the fasting glucose,insulin and lipids.Insulin sensitivity was assessed by HOMA-IR.Plasma visfatin levels were detected by ELISA.Results（1）Plasma visfatin level in PE group was higher than that in normal pregnant group.Furthermore,severe PE patients had the highest plasma visfatin concentrations compared to mild PE and normal pregnancies（P0.01）.（2） Correlation analysis showed that plasma visfatin levels were positively correlated with pre-BMI,DBP,FINS,HOMA-IR,TG,and FFAs（P0.05 or P0.01）and a negative correlation was found with HDL（P0.05）.Multivariate regression analysis found that pre-BMI（β=0.227,P0.05） and HOMA-IR（β=0.164,P0.05）were independent factors associated with plasma visfatin levels.Conclusion Plasma visfatin concentrations are significantly increased in patients with PE.It is higher in severe PE pregnancies than in mild PE.Maternal visfatin levels are closely correlated with the pathogenesis of PE.

关 键 词：子痫前期 内脂素 胰岛素抵抗 

分 类 号：R714.252[医药卫生—妇产科学]