姜黄素对鹌鹑实验性动脉粥样硬化的影响  

Effect of curcumin on experimental atherosclerosis in quail

作　　者：马利芹[1,2] 王迎春[1] 史晓涛[1] 徐倩倩[1] 张晓利[1] 王丽叶[1] 霍晓青[1] 陈立功[1] 董世山[1] 

机构地区：[1]河北农业大学动物科技学院,河北保定071001 [2]河北北方学院动物科技学院,河北张家口075131

出　　处：《中国兽医学报》2010年第12期1682-1685,共4页Chinese Journal of Veterinary Science

基　　金：河北省科技支撑计划资助项目(07220401D-01)

摘　　要：采用高脂饲料连续饲喂的方法建立鹌鹑实验性动脉粥样硬化动物模型,选择姜黄素进行干预,观察其对鹌鹑动脉粥样硬化主动脉变化和血脂水平的影响。结果显示,姜黄素可有效对抗内膜增厚和斑块形成,保护动脉血管的正常结构,同时血清TC、TG、LDL-C含量降低,HDL-C水平升高;提示姜黄素可有效改善鹌鹑动脉粥样硬化发生发展过程中的动脉硬化程度,并可有效抑制血脂含量,起到调节血脂代谢的作用。The curcumin was adopted to observe the changes of aortic atherosclerosis and plasma lipid levels in quail,with a view to provide experimental basis to anti-atherosclerosis.The results showed that curcumin can effective against intimal thickening and plaque formation,and protect the normal structure of arteries.In addition,the serum TC,TG,LDL-C levels decreased,and the serum HDL-C levels increased.All these indicated that curcumin could effectively improve atherosclerosis,inhibit lipid content,and play an important role in regulating lipid metabolism.

关 键 词：鹌鹑 动脉粥样硬化 姜黄素 血脂 

分 类 号：S853.7[农业科学—临床兽医学] S856.2[农业科学—兽医学]