保肝抗痨汤对实验性急性肝损伤的影响  

Effects of Bao-gan-kang-lao Decoction on Experimental Acute Hepatic Injury

作　　者：瞿融[1] 孙琪[1] 厉璐帆[2] 吴玉君[3] 古明[2] 马世平[2,4] 

机构地区：[1]南京中医药大学方剂教研室,南京210046 [2]中国药科大学中药药理教研室,南京210009 [3]南京市胸科医院,南京210029 [4]中国药科大学图书馆,南京210009

出　　处：《药学与临床研究》2010年第6期531-533,共3页Pharmaceutical and Clinical Research

基　　金：JALIS三期工程(编号JS2008-21)

摘　　要：目的:观察保肝抗痨汤对急性肝损伤的治疗作用。方法:采用CCl4和抗结核药利福平、异烟肼合用致小鼠急性肝损伤模型,连续给予保肝抗痨汤6 d,观察小鼠血清ALT、AST活性和肝指数的变化,并进行急性毒性试验。结果:保肝抗痨汤22、44 g生药/kg剂量组均能显著降低CCl4和抗结核药物所致急性肝损伤小鼠升高的血清ALT、AST水平以及肝指数,小鼠灌胃最大生药给药量为225 g.kg-1.d-1,为人临床用量的155倍。结论:保肝抗痨汤对CCl4和抗结核药物所致的小鼠肝损伤均有保护作用,且毒性小,临床用药安全可靠。Objective： To observe the protective effect of Bao-gan-kang-lao decoction on acute hepatic injury.Methods： The acute hepatic injury model of mice was induced by carbon tetrachloride and anti-tuberculosis drugs Rifampacin and Isoniazid.We measured the changes of serum ALT,AST and liver index after the administration of the Bao-gan-kang-lao decoction for 6 days,and observed the acute toxicity of Bao-gan-kang-lao decoction.Results： Bao-gan-kang-lao decoction with the dose of 22 and 44 g·kg-1·d-1 could obviously reduce the levels of ALT and AST and the coefficient of liver weight induced by carbon tetrachloride and anti-tuberculosis drugs Rifampacin and Isoniazid.The maximum dosage to mice was 225 g·kg-1·d-1 155 times of human clinical dosage.Conclusions： Bao-gan-kang-lao decoction has protective effect on liver injury induced by carbon tetrachloride and anti-tuberculosis drugs Rifampacin and Isoniazid.Bao-gan-kang-lao decoction has not much toxicity,and is safe and reliable in clinic.

关 键 词：保肝抗痨汤 四氯化碳 抗结核药物 肝损伤 肝保护 

分 类 号：R285.5[医药卫生—中药学]