富勒醇C_(84)(OH)_x的合成及Gd-DTPA掺杂体系纵向弛豫时间的测量  

Synthesis of Fullerenol C_(84)(OH)_x and Measurement on Longitudinal Relaxation Time of Doped Gd-DTPA

作　　者：何睿[1] 陈亮文[1] 黄志坚[1] 

机构地区：[1]杭州师范大学生物医药与健康研究中心,浙江杭州310012

出　　处：《杭州师范大学学报（自然科学版）》2010年第6期434-437,共4页Journal of Hangzhou Normal University(Natural Science Edition)

基　　金：浙江省医药卫生科研基金(2009A158);杭州市科技发展计划项目(20091133B09;20090231T04)

摘　　要：利用高效液相法分离的C84为原料,以改进的相转移催化剂作用下碱性反应法合成新型富勒醇C84(OH)x,通过MS、IR和元素分析确认其结构.通过MRI实验测量临床常用造影剂Gd-DTPA溶液中分别掺杂C84(OH)x及β-环糊精后体系水质子纵向弛豫时间,结果显示掺杂β-环糊精后无法改变体系的纵向弛豫率(R1),而掺杂C84(OH)x后使得体系的R1值提高.上述实验现象归咎于顺磁性的Gd-DTPA与C84(OH)x纳米颗粒间存在相互作用,这为探寻新型高弛豫率MRI造影剂提供了一条全新的研究思路.The experiment has synthesized water-soluble fullerenol C84（OH）x by the reaction of C84 with 50% NaOH containing TBAH and H2O2,and confirmed its structure by MS,LR and element analysis.Based on MRI experiment,the paper has measured the longitudinal relaxation time of water proton after doping C84（OH）x and β-cyclodextrin to Gd-DTPA.The results have showed that doped β-eyclodextrin cannot change the longitudinal relaxation ratio,but doped C84（OH）x can raise R1.The experiment phenomenon has indicated that there are interactions between Gd-DTPA and C84（OH）x,this result can provide a new way to explore new MRI contrast agents with high relaxation ratio.

关 键 词：富勒醇 掺杂 弛豫时间 磁共振成像 造影剂 

分 类 号：O613.7[理学—无机化学]