转化生长因子β1-509C/T、T869C基因多态性与妊娠期高血压疾病的相关研究  

Study on the correlation between gene polymorphisms of TGF-β1-509C/T,T869C and hypertensive disorder complicating pregnancy

作　　者：曾改鸿[1] 彭履冰[1] 钟丽红[1] 王晓晖[1] 朱宇 廖志琼[3] 陈盛强[3] 

机构地区：[1]南方医科大学附属深圳宝安区人民医院妇产科,广东深圳518101 [2]广东省深圳市福永医院妇产科 [3]广州医学院第二附属医院

出　　处：《中国妇幼保健》2010年第36期5482-5484,共3页Maternal and Child Health Care of China

摘　　要：目的:研究转化生长因子β1(TGFβ1)-509C/T、T869C基因多态性与妊娠期高血压疾病的相关性。方法:运用聚合酶链反应扩增TGFβ1-509C/T、T869C基因片段,内切酶进行限制性酶切反应并经测序证实。结果:观察组TGFβ1-509C/T基因多态性基因型频率(%)分别为18.18、43.94、37.88;对照组分别为14.71、45.59、39.70。观察组TGFβ1、T869C基因多态性基因型频率(%)分别为21.15、46.16、32.69;对照组分别为22.06、47.06、30.88。TGFβ1-509C/T、T869C各种基因型频率在两组之间的差异无统计学意义(P>005)。结论:TGFβ1-509C/T、T869C基因多态性与妊娠期高血压疾病无明显相关。Objective：To study the correlation between gene polymorphisms of transforming growth factor-β1（TGF-β1）-509C/T,T869C and hypertensive disorder complicating pregnancy（HDCP）.Methods：Gene fragments of TGF-β1-509C/T and TGF-β1-T869C were amplified by PCR,restriction endonuclease reaction was used by incision enzyme,then the genes were confirmed by gene sequencing.Results：The frequencies of gene polymorphism genotypes of TGF-β1-509C/T were 18.18%,43.94%,37.88% in observation group,14.71%,45.59%,39.70% in control group,respectively;The frequencies of gene polymorphism genotypes of TGF-β1-T869C were 21.15%,46.16%,32.69% in observation group,22.06%,47.06%,30.88% in control group,respectively;there was no significant difference between the two groups（P0 05）.Conclusion：There is no obvious correlation between gene polymorphisms of TGF-β1-509C/T,T869C and HDCP.

关 键 词：妊娠期高血压疾病 转化生长因子Β1 T869C 基因多态性 

分 类 号：R714.7[医药卫生—妇产科学]