口腔崩解片的崩解时间测定方法和制剂质量改进研究  

Progress of disintegration time tests and quality improvement for orally disintegrating tablets

作　　者：吴雯[1] 于凤波[2] 王永峰[2] 张灿[1] 

机构地区：[1]中国药科大学药学院,南京210009 [2]天津天士力集团研究院化学药物研究所,天津300190

出　　处：《世界临床药物》2010年第12期759-763,共5页World Clinical Drug

摘　　要：由于受检验及制剂技术、药品生产成本等诸多原因影响,我国口腔崩解片的发展受到一定限制。本文综述近年口腔崩解片体内外崩解时间的测定方法、制剂技术以及口感评价等检验和制剂制备相关技术与经验,以期推动国内口腔崩解制剂技术的发展。Because of insufficient analysis methods,preparation technique and production cost,the development of orally disintegrating tablets has some temporarily barriers in our country.This review introduces the methods about disintegration time tests of both in vitro and in vivo,preparation technique and taste-masking methods,for the purpose of promoting the improvement of the orally disintegrating technology in our country.

关 键 词：口腔崩解片 崩解时间 制剂技术 口感 

分 类 号：R944.4[医药卫生—药剂学] R927.1[医药卫生—药学]