骨钙素调控能量代谢的研究进展  

Research Progress in Osteocalcin for Regulation of Energy Metabolism

作　　者：周博[1] 徐琳[1] 孙宏志[1] 

机构地区：[1]西安交通大学医学院临床病理生理研究所,西安710061

出　　处：《医学综述》2010年第24期3681-3683,共3页Medical Recapitulate

基　　金：国家自然科学基金(30971392);教育部新世纪优秀人才计划项目(NCET-08-0435);西安交通大学"腾飞人才"基金项目(N160-0710040203)

摘　　要：脂细胞衍生激素可调控骨骼代谢,此现象提示骨骼也可通过反馈回路调控能量代谢。进一步的研究证明了骨钙素能介导能量代谢的调控,通过开放性实验明确了一种骨钙素修饰基因Esp,其可编码蛋白酪氨酸磷酸酶。在此综述骨钙素对能量代谢的调控、骨钙素生物活性的调控、骨钙素与肥胖症及2型糖尿病,以及骨钙素的临床研究进展。Recent studies show that adipocyte-derived hormone can regulate bone metabolism,implying that bone may exert a feedback regulation on energy homeostasis.Further studies have confirmed that osteocalcin can regulate energy metabolism.The first gene identified by this open-ended search is Esp,which encodes osteotesticular protein tyrosine phosphatase（OST-PTP）.This article reviews the research progresses in osteocalcin regulating energy metabolism,modulation of its biological activity,relation with obesity and type 2 diabetes,and its clinical researches.

关 键 词：骨钙素 能量代谢 肥胖症 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]