低压缺氧对原发性高血压大鼠血压的影响  

Effects of hypobaric hypoxia on blood pressure of essential hypertensive rat

作　　者：张司兰 徐立群 彭禄荣 韩威[2] 

机构地区：[1]重庆市璧山县人民医院心血管内科,402760 [2]成都医学院医学检验系实验中心,610083

出　　处：《重庆医学》2010年第24期3333-3335,共3页Chongqing medicine

摘　　要：目的观察低压缺氧对原发性高血压(EH)大鼠血压的影响。方法将12周龄EH大鼠随机分为常氧组和低压缺氧组,低压缺氧分别模拟海拔4 000 m和6 000 m;于实验第4、8周末测量血压,尾静脉取血检测血管紧张素Ⅱ1型受体(AT1)mRNA和血管紧张素转换酶2(ACE2)蛋白和mRNA的表达。结果低压缺氧能明显升高EH大鼠的血压,全血AT1 mRNA、ACE2蛋白和mRNA表达显著增高(P<0.05)。结论低压缺氧能升高EH大鼠的血压,其机制可能与AT1、ACE2的表达增高有关。Objective To observe effects of hypobaric hypoxia on blood pressure of essential hypertensive rat.Methods The 12 weeks old essential hypertensive rats were randomly divided into hypobaric hypoxia group and normal oxygen concentration group,and the hypobaric hypoxia groups were apart imitated 4 000 m and 6 000 m height.The blood pressure,AT1 mRNA,ACE2 mRNA and protein in blood were measured in fourth week and eighth week.Results In hypobaric hypoxia groups,The blood pressure,AT1 mRNA,ACE2 mRNA and protein in blood were increased markedly（P〈0.05）.Conclusion hypobaric hypoxia could increase blood pressure of essential hypertensive rat.This maybe be concerned with increase of AT1 mRNA,ACE2 mRNA and protein.

关 键 词：高血压 血管紧张素Ⅱ1型受体 血管紧张素转换酶2 缺氧 

分 类 号：R544.102[医药卫生—心血管疾病]