Ang-2和Livin在子宫内膜异位症组织中表达的研究  

Study on the Expression of Ang-2 and Livin in the Tissues of Endometriosis

作　　者：闫琼琼[1] 朱新群[1] YAN Qiong-qiong, ZHU Xin-qun （Department of Obstetrics and Gynecology,Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China）

机构地区：[1]郑州大学第二附属医院妇产科,河南郑州450014

出　　处：《医学信息》2011年第2期306-307,共2页Journal of Medical Information

摘　　要：目的探讨促血管生成因子Ang～2和凋亡抑制蛋白Livin在子宫内膜异位症发生发展中的作用。方法应用免疫组织化学SP法检测40例子宫内膜异住症的卵巢巧克力囊肿组织（异位内膜组织）和30例正常子宫内膜组织标本中Ang-2和Livin的表达情况。结果Ang～2在异位内膜组织中的阳性表达率为87．50％，高于其在正常内膜中的阳性表达率16．66％，Livin在组织中的阳性表达率为72．50％，显著高于其在正常内膜中的阳性表达率13．33％。并且两者在EM卵巢巧克力囊肿组织中的表达呈正相关。结论Ang-2和Livin可能在EM卵巢巧克力囊肿的发生发展中发挥着重要作用。Objective To detect the role of Aug-2 and Livin in the development of endometriosis.Methods Arehived tissue sample of 40 Ovary chocolate cyst （eutopic）and 30 normal endometrium we selected and immunohistochemically analyzed for Ang-2 and Livin. Results the positive rate of Ang-2 in endometriosis was 87.50% higher that in noemal endometrium of 16.66%, the positive rate of Livin in endometriosis was 72.50% higher that in noemal endometrium of 13.33%.They have positive relationship in endometriosis. Conclusions Ang-2 and Livin may play an important role in particular malignant biological behaviour of endometriosis through their repective moclear mechanisn.

关 键 词：Ang-2和Livin 子宫内膜异位症 免疫组织化学 

分 类 号：R711.71[医药卫生—妇产科学;医药卫生—临床医学]