丹参涂膜剂对肥厚性瘢痕裸鼠模型血液流变学及细胞因子TGF-β1、bFGF的影响  

Influence of Danshen external-using paints on the microcirculation of the Hypertrophic scar tissue and the expression of TGF-β1 and bFGF

作　　者：冀黎平[1] 张建华[1] 余安胜[2] 

机构地区：[1]上海中医药大学,上海201203 [2]上海中医药大学曙光医院,上海201203

出　　处：《中华中医药杂志》2011年第1期135-137,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：上海市科委基金资助项目(No.03CQ28)~~

摘　　要：目的:研究丹参涂膜剂对肥厚性瘢痕裸鼠模型微循环及细胞因子TGF-β1、bFGF的影响。方法:利用微循环检测仪分别在实验初期、中期(用药4周)、末期(用药8周)观察各组瘢痕内毛细血管形态,毛细血管流态,毛细血管与周围组织吻合状况,并计数微血管;免疫组化EnVision法检测TGF-β1、bFGF表达。结果:丹参涂膜剂可改善增生期瘢痕微循环局部缺氧状态,抑制成熟过渡期瘢痕微循环血供,也可显著降低TGF-β1在肥厚性瘢痕中光密度值(P<0.05),增加bFGF在肥厚性瘢痕中光密度值(P<0.05)。结论:丹参涂膜剂可改善肥厚性瘢痕微循环状态,下调TGF-β1、上调bFGF的表达。Objective：To investigate the effects of Danshen external-using paints on microcirculation of the hypertrophic scar tissue.Methods：observe the microcirculation of the Hypertrophic scar tissue 1 week,4 weeks,8weeks after the treatment of Danshen external-using paints respectively,and detected the expression of TGF-β1 and bFGF by EnVision.Results：The results showed that the Danshen external-using paints obviously improve the partly oxygen deficit condition of the HS microcirculation in proliferative phase,inhibit the blood-supply of HS microcirculation in maturation stage,and obviously lower the optical density value of TGF-β1 in hypertrophic scar（P0.05）,meanwhile increase the optical density value of bFGF in hypertrohpic scar（P0.05）.Conclusions：the Danshen external-using paints can improve its microcirculation,and down-regulate the expression of TGF-β1,and up-regulate the expression of bFGF.

关 键 词：丹参 涂膜剂 肥厚性瘢痕 微循环 细胞因子 

分 类 号：R285.5[医药卫生—中药学]