通塞脉片对动脉粥样硬化大鼠CD40及CD40L表达的影响  

Effect of TSM on expression of CD40 and CD40L in AS Rats

作　　者：朱青[1] 胡晨[1] 蒋凤荣[1] 殷书梅[2] 卞慧敏[1] 

机构地区：[1]南京中医药大学中医药研究院,南京210029 [2]江苏南星药业有限责任公司江苏省中药药效与安全性评价重点实验室,南京210029

出　　处：《中华中医药杂志》2011年第1期160-162,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金(No.30873401)~~

摘　　要：目的:观察通塞脉片(TSM)对大鼠动脉粥样硬化(AS)的治疗作用并探讨其作用机制。方法:通过饲喂高脂饲料加维生素D3建立大鼠AS模型,给予TSM治疗后,观察血管形态学、白细胞表面分化抗原40(CD40)、白细胞表面分化抗原40配体(CD40 Ligand,CD40L)在血管中表达以及血清中炎症因子C反应蛋白(CRP)变化。结果:TSM可以显著改善AS大鼠动脉形态学的改变,降低其血清中炎性因子CRP的含量:模型组(8.19±2.82)mg/L,辛伐他汀组(5.19±1.89)mg/L,TSM组高剂量(5.17±2.60)mg/L,低剂量(5.24±2.52)mg/L(P<0.05),同时抑制血管中CD40、CD40L的表达(P<0.05,P<0.01)。结论:TSM通过降低体内的炎症水平而达到治疗AS作用。Objective： To examine the therapeutic effect of Tongsaimai Pills（TSM）on antiatherosclerosis（AS）and the mechanism involved.Methods： Athero-sclerosis model was established by feeding rats with high fat diet and VD3.After eight weeks of TSM administration,C-reactive protein（CRP） was measured.CD40 and CD40 Ligand（CD40L）were examined by immunohistochemistry.Morphological changes of aorta were observed under gross,light and electron microscopes.Results： Morphological changes in AS were altered by TSM.Serum CRP level and the expression of CD40 and CD40L C were decreased by TSM.Conclusion： TSM could alleviate AS and this may related to its effect on CD40 and CD40L.VEC was protected and proliferation of SMC was depressed and atherosclerotic plaque was stabilized by TSM.

关 键 词：动脉粥样硬化 通塞脉片 C反应蛋白 白细胞表面分化抗原40 白细胞表面分化抗原40配体 

分 类 号：R285.5[医药卫生—中药学]