左氧氟沙星替代吡嗪酰胺治疗结核性渗出性胸膜炎的临床研究  

The clinical effect of levofloxacin substituting pyrazinamide in treatment of tuberculosis transudatory pleuritis

作　　者：李继琼[1] 颜浩[1] 

机构地区：[1]成都市第二人民医院呼吸科,四川成都610017

出　　处：《西部医学》2011年第1期57-58,61,共3页Medical Journal of West China

摘　　要：目的评价左氧氟沙星替代治疗结核性渗出性胸膜炎的疗效。方法随机将47例结核性渗出性胸膜炎患者分为Z组和L组,分别用包含吡嗪酰胺及包含左氧氟沙星化疗方案治疗,并比较两组患者的治疗效果。结果两组治疗疗效无显著性差异(P>0.05),副反应有显著性差异(P<0.05)。结论左氧氟沙星替代吡嗪酰胺治疗结核性渗出性胸膜炎取得了与含吡嗪酰胺方案一样的临床效果,且副作用明显减少。Objective To evaluate the clinical effects of levofloxacin substituting pyrazinamide in treating tuberculous transudatory pleuritis patients. Methods 47 patients with tuberculous transudatory pleuritis were randomized to Z group and L group, 23 patients in Z group were treated with pyrazinamide combined with other antituberculotics, and 24 patients in L group were treated with levofloxacin combined with other antituberculotics. The clinical treatment outcomes were observed. Results There were no significant differences in treatment effect between two groups, but there were significant differences in the side effects. Conclusion levofloxacin substituting pyrazinamide in treating tuberculous transudatory pleuritis has the same treatment effect as pyrazinamide.

关 键 词：左氧氟沙星 替代 吡嗪酰胺 结核性渗出性胸膜炎 

分 类 号：R521.7[医药卫生—内科学]