早期日本血吸虫感染长爪沙鼠动物模型的建立  

Study on Early Infection of Schistosomiasis japonicum with Gerbil Models

作　　者：柳建发[1] 蒋雯雯[1] 胡奇丰[1] 周飞[1] 

机构地区：[1]宁波大学医学院,浙江宁波315211

出　　处：《宁波大学学报（理工版）》2011年第1期95-96,共2页Journal of Ningbo University：Natural Science and Engineering Edition

基　　金：浙江省科技厅科技计划项目(2009F80003);浙江省教育厅科研项目(Y200803083)

摘　　要：实验应用双抗体夹心免疫吸附试验(Double Antibodies-ELISA ELISA)检测获得感染鼠血清的循环抗体,所用抗原由日本血吸虫成虫和虫卵抗原免疫长爪沙鼠而获得.实验结果证明,用该试验检测长爪沙鼠感染日本血吸虫后6周内各期的抗体有高度的特异性,可为日本血吸虫感染模型的建立和考核疗效提供参考.Study of early infection of Schistosoma japonicum with gerbial animal models is conducted in this paper. In the experiment, the protein antibodies fusion is obtained using double antibodies-ELISA. The results show that, within the 6-week timeframe, the antibodies have developed the high speciality. The findings from this investigation may offer referential insights into the modeling of schistosoma infection as well as the evaluation of the medical performance.

关 键 词：日本血吸虫感染 长爪沙鼠 动物模型 双抗体夹心免疫吸附试验 

分 类 号：R383.24[医药卫生—医学寄生虫学]