脂化前列腺素E1对糖尿病大鼠尿微量清蛋白的影响及其机制的研究  

Research on Effects and Mechanism of lipid-prostaglandin E1 on microalbuminuria in Diabetic Rats

作　　者：孙香[1] 冯玉欣[2] 赵艳艳[1] 刘慧萍[1] 

机构地区：[1]潍坊医学院,山东潍坊261041 [2]山东省潍坊市人民医院内分泌科,山东潍坊261041

出　　处：《医学信息（中旬刊）》2011年第1期4-5,共2页Medical Information Operations Sciences Fascicule

摘　　要：目的:研究脂化前列腺素E1对糖尿病大鼠尿微量白蛋白的影响并探讨其机理。方法:45只大鼠随机分为4组,其中3组糖尿病肾病模型分别给予生理盐水、PGE1和罂粟碱治疗20天,测量大鼠24h尿微量白蛋白,观察大鼠肾脏组织病理改变,并检测大鼠血糖及血肌酐值。结果:PGE1治疗组大鼠尿微量白蛋白及血肌酐值明显降低,与糖尿病组及罂粟碱治疗组均有显著性差异,P<0.05。结论:PGE1可明显改善糖尿病大鼠尿微量白蛋白含量,保护肾功能,其作用明显优于罂粟碱。Objective：To research the effects and mechanism of lipid - prostaglandin E1 （ PGE1） on rnicroalbuminuria in Diabetic Rats. Methods ：45 rats were randomly divided into four groups, model rats with diabetic nephropathy were respectively given saline,PGE1 and dispamil treatment for 20 days. Detect 24h urinary albumin concentration（24hALB） ,blood glucose（BS） and serum creatinine （Ser） , observe pathological changes in kidney. Result ：24hALB and Ser were significantly lower in PGE1 treatment group than diabetic control group and dispamil treatment group, P 〈 0.05. Conclusion ： PGE1 significantly improve 24hALB and kidney function of diabetic rats.which was suoerrior to disoamil.

关 键 词：糖尿病肾病 前列腺素E1 尿微量白蛋白 

分 类 号：R587.2[医药卫生—内分泌]