注射用丹参多酚酸盐结合经皮冠脉介入术治疗非ST段抬高型心肌梗死临床观察  

Clinical observation of salvianolate with percutaneous cardial intervention in treating non-ST-elevated myocardial infarction

作　　者：倪岚[1] 许澎[1] 伍旭升[1] 

机构地区：[1]复旦大学附属上海市第五人民医院心内科,上海200240

出　　处：《上海中医药杂志》2011年第1期41-43,共3页Shanghai Journal of Traditional Chinese Medicine

摘　　要：目的观察丹参多酚酸盐结合经皮冠脉介入术(PCI)治疗非ST段抬高型心肌梗死(NSTEMI)的疗效。方法将160例患者随机分为治疗组、对照组各80例,两组均常规西药治疗,并在发病1周内行PCI术,治疗组再加用丹参多酚酸盐200mg,每天1次治疗,两组均以10天为1个疗程。治疗前后观察两组血清肌钙蛋白I(TNI)、高敏C反应蛋白(hCRP)、脑钠肽(BNP)水平。结果两组治疗后TNI、hcRP、BNP均明显降低(P<0.05);组间治疗后比较,各指标差异均有统计学意义(P<0.05)。结论丹参多酚酸盐能够对抗NSTEMI患者的心肌细胞坏死,消除冠状动脉粥样硬化炎症反应,改善心功能,降低心肌缺血/再灌注损伤。Objective To observe the effects of salvianolate with percutaneous myocardial intervention（PCI） in treating non-ST-elevated myocardial infarction.Methods A total of 160 subjects were randomized into two groups（80 cases in each group） and treated by routine modern medicine and PCI;treatment group was additionally given salvianolate（200mg/d）.The treatment was given once a day and 10 days made up one course.The levels of serum TNI,BNP and hCRP were detected in both groups.Results The levels of TNI,BNP and hCRP were decreased in the treatment group.Conclusion Salvianolate can fight the necrosis of the myocardial cell,eliminate the inflammation of the coronary atherosclerosis,improve the heart function and reduce the myocardial reperfusion injury.

关 键 词：非ST段抬高型心肌梗死 冠脉介入术 丹参多酚酸盐 缺血/再灌注损伤 

分 类 号：R542.22[医药卫生—心血管疾病]