清胃黄连片的质量标准  

Study on Quality Standard of Qingwei Huanglian Tablets

作　　者：桂蜀华[1] 李业荣[1] 梁远园[1] 倪晨[1] 王倩[2] 

机构地区：[1]广州中医药大学新药开发研究中心,广州510006 [2]广州中医药大学中药学院

出　　处：《中国药师》2011年第1期49-51,共3页China Pharmacist

摘　　要：目的:建立清胃黄连片的质量控制标准。方法:采用薄层色谱法对清胃黄连片中黄芩、黄连、黄柏、甘草、知母、桅子、赤芍进行定性鉴别,采用高效液相色谱法对清胃黄连片中的黄芩苷进行含量测定。结果:黄芩、黄连、黄柏、甘草、知母、桅子、赤芍可在不同的薄层条件下分别检出;利用高效液相色谱法测定制剂中黄芩的有效成分黄芩苷,黄芩苷在0.20～1.60μg范围内线性关系良好(r=0.999 8),平均回收率为98.46%,RSD为2.89%(n=6)。结论:该法专属性强,重复性好,可用于清胃黄连片的质量控制。Objective： To establish quality standard of qingwei huanglian tablets. Method： Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Glycyrrhizae, Rhizoma Anemarrhenae, Fructus Gardeniae, Radix Paeoniae Rubra in the tablets were identi- fied by TLC; the content of baicalin was determined by HPLC. Result： Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Glycyrrhizae, Rhizoma Anemarrhenae, Fructus Gardeniae, Radix Paeoniae Rubra could be detected in different TLC conditions. The linear range of baicalin was 0. 20-1.60 μg （ r = 0. 999 8 ）. The average recovery was 98.46% with RSD of 2. 89% （ n = 6）. Conclusion： The method is specific and reproducible. It can be used for quality control of qingwei huanglian tablets.

关 键 词：清胃黄连片 质量标准 黄芩苷 薄层色谱法 高效液相色谱法 

分 类 号：TQ460.72[医药卫生—药物分析学]