不同麻醉药物对大鼠胃排空影响的初步研究  

Effect of Different Anesthetic Drugs on Gastric Emptying in Rats

作　　者：尹红[1] 严祥[1] 刘纯[2] 陈明[2] 张喜娟[1] 

机构地区：[1]兰州大学第一医院干部病房,兰州730000 [2]兰州大学第一医院核医学科,兰州730000

出　　处：《四川动物》2011年第1期115-117,共3页Sichuan Journal of Zoology

基　　金：2009年甘肃省医药卫生科研项目(GSWST09-04)

摘　　要：目的比较不同麻醉药对大鼠胃排空的影响。方法将40只Wistar大鼠随机分为乙醚组、硫喷托钠组、水合氯醛组、乌拉坦组和对照组。实验组分别用不同麻醉药进行麻醉,对照组不予任何麻醉药物。以单光子发射计算机断层扫描成像技术检测胃半排时间。结果与对照组比较,乙醚组胃半排时间略有延长,但差异无统计学意义(P>0.05);硫喷托钠组半排时间与对照组重叠较好,并具有更小的离散趋势;水合氯醛组半排时间明显延长,与对照组相比差异有统计学意义(P<0.01);乌拉坦对胃排空的抑制作用最大,12h几乎无胃排空。结论在进行大鼠活体的胃动力研究时,硫喷托钠是较为适宜的一种麻醉药物;乙醚具有操作简单、易得的优点,也不失为一种良好的选择;因乌拉坦对胃肠动力具有明显的抑制作用,实验时应尽量避免使用。Objective To study the effect of different anesthetic drugs on gastric emptying in rats. Methods 40 Wistar rats were randomly divided into 5 groups： thiopental sodium, anaesthetie ether, chloraldurat, urethane, and the control. Experimental groups were administered different anesthetic drugs; the control group was not given any drug. Single-photon emission computed tomography was used to detect gastric emptying time. Results Gastric emptying was lightly delayed in ether group with half emptying time （ P 〉 0. 05 ） ; the half emptying time of the thiopental sodium group is very similar to the control group; the half emptying time of the ehloraldurat group is significantly delayed （P 〈 0. 01 ） ; urethane showed ahnost no gastric emptying in 12 hours. Conclusions According to the results of our experiments, we suggest that in the experiments about effects of gastric motility in rats, thiopental sodium should be the anesthetic drug used. However, ether may be another choice as it＇s easy to use and obtain. Urethane should be avoided due to its significant inhibition on gastrointestinal motility.

关 键 词：大鼠 麻醉 胃排空 

分 类 号：R965[医药卫生—药理学]