α-酮戊二酸对脂多糖多次刺激后断奶仔猪生长性能、血液生化指标和内脏器官指数的影响  

Effect of α-ketoglutaric acid on growth performance,blood biochemical measurements and visceral organ index of weaned pigs after repeated LPS-stimulation

作　　者：王友炜[1] 侯永清[1] 丁斌鹰[1] 付大波[1] 

机构地区：[1]武汉工业学院动物营养与饲料科学湖北省重点实验室,湖北武汉430023

出　　处：《中国兽医学报》2011年第1期141-144,共4页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金资助项目(30871801);湖北省自然科学基金计划创新群体资助项目(2007ABC009)

摘　　要：试验选取24头体质量为(6.79±0.32)kg的断奶仔猪(杜洛克×长白×大约克)随机分成4个处理组,每个处理设6个重复(猪),2×2因子设计。在试验的第10、13、15天对应激组的猪腹腔注射100μg/kg LPS,非应激组注射等量的生理盐水。结果显示:(1)日粮添加1%AKG对非应激期仔猪生长性能无显著性影响(P>0.05);(2)日粮添加1%AKG可以缓解LPS多次刺激引起断奶仔猪的平均日增重的下降(P<0.05);(3)LPS多次刺激下,日粮中添加1%AKG降低了猪血液中总蛋白(P<0.05)和球蛋白的含量(P<0.01),提高了白蛋白/球蛋白(P<0.01);(4)LPS多次刺激导致猪脾脏器官指数显著增加(P<0.05)。结果表明,1%AKG在一定程度上能缓解LPS多次刺激导致的生长抑制和应激反应。An experiment was conducted to study the effect of α-ketoglutaric acid（AKG） on growth performance,blood biochemical measurements and visceral organ index of weaned pigs after lipopolysaccharide（LPS）-stimulated repeatedly.24 healthy crossbred（Duroc×Landrace×Largewhite） weanling piglets,weighing（6.79±0.32） kg,were randomly allocated to 4 treatments in a 2×2 factorial design.with 8 replications each（pigs）.Piglets in the LPS control group were intraperitoneally injected with 100 μg/kg LPS every other day（at 10,13 and 15 d after experiment）,whereas piglets in the control group were injected with the same dose of normal saline.The results showed that：（1） 1% AKG had no significant impact on the growth performance of non-stress period in piglets;（2）1% AKG alleviated the decrease of ADG induced by LPS-stimulation repeated（P0.05）;（3） After challenged repeated with LPS,total protein and globulin of the AKG group was decreased（P0.01） and ALB/GLB was increased（P0.01）;（4） LPS-stimulation repeated increased the absolute weight and the relative weight of spleen（P0.05）.The results indicated that dietary supplementation with 1%AKG can alleviate the growth depression and stress response induced by LPS to some degree.

关 键 词：脂多糖 断奶仔猪 生长性能 血液生化指标 内脏器官指数 

分 类 号：S828.1[农业科学—畜牧学]