醒脑静与尼可刹米分别联合无创正压机械通气治疗呼吸衰竭并肺性脑病的对比研究  

Therapeutic effect of Xingnaojing injection combined with non-invasive positive airway pressure mechanical ventilation on COPD complicated with respiratory failure and pulmonary encephalopathy

作　　者：陈宝华[1] 苏强[1] 左志通[1] 王旭[1] 张彩娣[1] 邹新中[1] 史建平[1] 

机构地区：[1]无锡市第三人民医院呼吸内科,江苏无锡214000

出　　处：《中国医院药学杂志》2011年第1期48-50,共3页Chinese Journal of Hospital Pharmacy

基　　金：江苏省中医药管理局资助项目(编号:LZ09106)

摘　　要：目的:对比研究醒脑静与尼可刹米分别联合无创正压机械通气(NIPPV)治疗呼吸衰竭并肺性脑病的临床疗效。方法:随机将84例COPD呼吸衰竭合并肺性脑病轻中型患者分为醒脑静联合无创正压机械通气治疗组(治疗组)与尼可刹米联合NIPPV治疗组(对照组);2组均在NIPPV基础上予平喘、祛痰、抗感染等治疗,治疗组加用醒脑静,对照组加用尼可刹米。结果:治疗组与对照组格拉斯哥评分、血气分析、机械通气时间、气管插管率的结果比较,经统计学处理,差异有显著性(P<0.05)。结论:本观察证明醒脑静联合NIPPV治疗COPD呼吸衰竭合并肺性脑病较尼可刹米联合NIPPV治疗COPD呼吸衰竭合并肺性脑病临床疗效更佳。OBJECTIVE To observe the clinical effectiveness of Xingnaojing injection or nikethamide combined with non-invasive positive airway pressure mechanical ventilation on chronic obstructive pulmonary disease （COPD） complicated with respiratory failure and pulmonary encephalopathy. METHODS Eighty-four patients of pulmonary encephalopathy were allocated randomly into the treatment group and the control group. The therapeutic method for the both groups including regular treat- ment and NIPPV, treatment group was injected Xingnaojing; control group was injected with nikethamide. RESULIS Glas- gow coma score, the arterial blood gases, hopitalized time, tracheal intubation rate between two groups had significant difference （P〈0. 05）. CONCLUSION This study demonstrated that the effect of non-invasive positive airway pressure mechanical venti lation combined with Xingnaojing injection was Better than that with nikethamide iniection for the treatment of COPD complicated with respiratory failure and pulmonary encephalopathy in clinic.

关 键 词：醒脑静 尼可刹米 肺性脑病 无创正压机械通气 

分 类 号：R969[医药卫生—药理学]