陕西省甲型H1N1流感人群感染状况调查  

Prevalence of influenza A(H1N1) infection among residents of Shaanxi province

作　　者：王敬军[1] 许晶[1] 张蕾[1] 史伟[1] 周体操[1] 邓勇[1] 余鹏搏[1] 郭晓荣[1] 张义[1] 

机构地区：[1]陕西省疾病预防控制中心病毒研究室,西安710054

出　　处：《中国公共卫生》2011年第1期1-3,共3页Chinese Journal of Public Health

摘　　要：目的分析甲型H1N1流感疫情的时间分布特征和检测抽样人群血凝抗体水平,拟合人群实际感染和免疫状况。方法对陕西省的甲型H1N1流感全部、重症和死亡病例进行时间分布描述,并在流行高峰后第2、4个月,对9 006名分层整群抽样人群进行甲型H1N1流感血凝抗体检测。结果甲型H1N1流感的流行经过了输入期、国内流行期、快速放大期、危重病例出现期和流行高峰后期等5个流行过程;流行高峰后,甲型H1N1流感血凝抗体阳性率大城市高于中小城镇和农村,男性高于女性,6~17岁中小学年龄段人群阳性率最高,60岁~人群最低,人群隐性感染率23.40%;感冒对甲型H1N1流感抗体形成的超额贡献率为4.87%;接种甲型H1N1流感疫苗的净阳转率为25.10%,在1∶20以上各滴度中,接种组抗体形成率高于非接种组0.75~1.52倍。结论甲型H1N1流感流行经历了5期过程,人群隐性感染率23.40%,接种甲型H1N1流感疫苗的净阳转率为25.10%。Objective To explore the relationship between influenza A（H1N1） infection and immune status among residents in Shaanxi province by analysis of cases distribution and serum antibody detection.Methods Time distribution of influenza A（H1N1） cases was analyzed.Two and four months after the epidemic peak,the hemagglutinin antibody of influenza A（H1N1） was detected in the subjects selected with random sampling.Results The epidemic pattern of influenza A（H1N1） included five periods.They were import period,epidemic period in homeland,rapid amplification period,severe case occurrence period,and post-period of epidemic.After the outbreak,the level of hemagglutinin antibody of influenza A（H1N1） was higher in the city than in the rural area and higher in men than in women.The persons of 6-17 years old had a higher level of antibody and the people of ≥60 years old had lower antibody level.The recessive infectious rate was 23.40%.The pure positive rate of the antibody was 25.10% after massive influenza A（H1N1） vaccination.Among the subjects with higher antibody titer than 1：20,the antibody level in vaccinated group was 1.75 to 2.52 times higher than that of in non-vaccinated group.Conclusion There are 5 periods for influenza A（H1N1） epidemic.The recessive infectious rate is 23.40%.The pure positive rate of the antibody is 25.10% after influenza A（H1N1） vaccination.

关 键 词：甲型H1N1流感 流行模式 抗体形成 

分 类 号：R183.3[医药卫生—流行病学]