比索洛尔治疗充血性心力衰竭对血浆脑钠肽水平的影响  

Influence on plasma brain natriuretic peptide level by use of Bisoprolol for congestive heart failure

作　　者：李大伟[1] 周发展[2] 

机构地区：[1]山东省新泰市人民医院,271200 [2]山东省泰安市中心医院心内科

出　　处：《中国实用医刊》2011年第1期59-60,共2页Chinese Journal of Practical Medicine

摘　　要：目的观察比索洛尔治疗充血性心力衰竭后患者血浆脑钠肽（BNP）水平的改变。方法选择心功能Ⅲ～Ⅳ级的心力衰竭患者124例，在常规抗心衰基础上加用比索洛尔，观察治疗前后血浆脑钠肽水平的变化。结果治疗后患者心率明显减慢，血压较治疗前降低，左室舒张末期内径缩短，而左室射血分数则较治疗前升高，应用比索洛尔后BNP值明显降低。结论比索洛尔治疗充血性心力衰竭的总有效率达80％以上，且BNP明显下降。提示动态监测患者血浆BNP水平可以帮助了解治疗效果及判断预后。Objective To observe plasma brain natriuretic peptide level by use of bisoprolol for congestive heart failure. Methods We chose 124 heart failure patients with Ⅲ - IV New York Heart Asso- ciation （NYHA） functional classification, arid used bisoprolol on the basis of traditional treatment, then observed the changement of plasma brain natriuretic peptide level during treatment. Results After treatment, patients＇ s heart rate, blood pressure, LVDd all descended, but LVEF increased. The value of BNP declined obviously after the use of the bisoprolol. Conclusions We treated congestive heart failure with bisoprolol, the availability ratio was more than 80%, and the value of BNP declined obviously. It implied that dynamic monitoring plasma brain natriuretic peptide was helpful in understanding treatment effect and prognosis. [

关 键 词：脑钠肽 比索洛尔 充血性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]