比索洛尔与培哚普利联合对慢性心衰患者血浆pro-bnp水平干预作用研究  

Research on the intervention effect of serum pro-bnp of bisoprolol combined with perindopril in patients with chronic heart failure

作　　者：胡兆霆[1] 梁燕琼[1] 侯庆臻[1] 丁亚楠[1] 陈毅华[1] 卓茹[1] 

机构地区：[1]南方医科大学第三附属医院心内科,广州510630

出　　处：《国际医药卫生导报》2011年第1期63-66,共4页International Medicine and Health Guidance News

摘　　要：目的 探讨比索洛尔与培哚普利联合对慢性心衰患者血浆脑钠肽前体（pro-bnP水平的干预作用.方法 选取本院收治的120例慢性心衰患者,随机分为3组,每组40例,即比索洛尔组、培哚普利组和比索洛尔联合培哚普利组,测定治疗前后血浆pro-bnp水平,观察疗效.结果 联合治疗组总有效率为95.0%,显著优于比索洛尔组（80.0%）和培哚普利组（77.5%）,P＜0.05,治疗后血浆pro-bnp水平联合治疗组显著低于比索洛尔组和培哚普利组,P＜0.05.结论 比索洛尔和培哚普利联合用药能够显著降低患者的血浆pro-bnp水平,疗效确切.Objective To investigate the intervention effect of serum pro-bnp of bisoprolol combined with perindopril in patients with chronic heart failure Methods 120 cases with chronic heart failure of our hospital were randomly divided into 3 groups, bisoprolol group, perindopril group and bisoprolol combined with perindopril group, 40 cases for each group, the serum pro-bnp was determined before and after treatment, observed the curative effect.Results The total effective rate of combined treatment group was 95.0%, that was better than the bisoprolol group （80.0%） and perindopril group （77.5%）,P〈0.05 ,after treatment, the level of serum pro-bnp of combined treatment group was less than that of bisoprolol group and perindopril group, P〈0.05.Conclusion bisoprolol combined with perindopril can decrease the level of serum pro-bnp significantly, the curative effect is exact.

关 键 词：慢性心衰 比索洛尔 培哚普利 

分 类 号：R541[医药卫生—心血管疾病]