冠心病合并糖尿病患者糖化血红蛋白水平与心脏结构和NT-proBNP的相关性研究  

Research on the correlation of the glycosylated haemoglobin Ale level and cardiac structure,NT-proBNP of the patients with the senile coronary heart disease and diabetes mellitus

作　　者：陈益民[1] 刘海燕[1] 张春云[1] 

机构地区：[1]广州医学院港湾医院内科,510700

出　　处：《国际医药卫生导报》2011年第2期149-151,共3页International Medicine and Health Guidance News

摘　　要：目的 探讨老年冠心病合并糖尿病患者糖化血红蛋白水平与心脏结构和NTproBNP的相关性.方法 选取我院门诊和内科收治的老年冠心病合并糖尿病患者120例,根据糖化血红蛋白（HbAlc）水平分为A细（HbAlc〈7%）和B组（HbA1c≥7%）,利用彩色超声诊断仪进行彩色多普勒超声心动图测量心脏结构,包括室间隔舒张来期厚度（IVSTD）、左室后壁舒张末期厚度（LVPWTD）、左室舒张末期的内径（LVEDd）和舒张早期最大血流速度/舒张晚期最大血流速度（E/A）,并评价心功能,射血分数（EF）和NT-pro BNP水平,比较两组上述指标的差异.结果 彩色多普勒超声心动图显示,IVSTD A组为（8.97±0.78）mm,B组为（11.32±0.64）mm,LVPWTDA组为（9.16±0.68）mm,B组为（11.45±1.64）mm,LVEDd A组为（47.23±2.09）mm,B组为（54.56±2.18）mm,B组患者的心脏结构改变程度较A组患者明显加重（P〈0.05）,NT-proBNP水平B组较A组明显增高[（723±127）ng/L vs（586±138）ng/L]（P〈0.05）.结论 糖尿病为冠心病的易发因素,HbAlc可反映冠心病合并糖尿病患者的心脏结构改变程度,与心功能严重程度呈正相关.Objective to study the correlation of the glycosylated haemoglobin Alc level and cardiac structure, NT-proBNP of the patients with the senile coronary heart disease and diabetes mellitus.Methods Randomly selected 120 patients of senile coronary he art disease complicated with diabetes mellitus.120 patients were divided into A group（HbAlc〈7%）and B group（HbAlc≥7%）according to diglycosylated haemoglobin Alc level. Using color ultrasonic diagnostic apparatus, measured cardiac structure, such as IVSTD, LVPWTD, LVEDd, E/A, EF, and the level of NT-pro BNP, compared with these indexes. Results Color doppler echocardiography showed that IVSTD of A group was （8.97 ± 0.78） mm, B group was （11.32 ± 0.64） mm, LVPWTD of A group was（9.16 ± 0.68） mm, B group was（11.45 ± 1.64） mm, LVEDd of A group was（47.23 ± 2.09） mm, B group was（54.56 ± 2.18） mm, the cardiac structure of B group was more serious than A group （P〈0.05）, the level of NT-pro BNP of B group was higher than A group [（723 ±127）ng/L vs（586 ± 138）ng/L] （P〈 0.05）.Conclusion Diabetes mellitus is easy-happening factors of coronary heart disease, HbAlc can reflect the change degree of cardiac structure of coronary heart disease complicated with diahetes mellitus, it is positive correlation with severity of cardiac function.

关 键 词：冠心病 糖尿病 糖化血红蛋白 心脏结构 NT—proBNP 

分 类 号：R587[医药卫生—内分泌] R541[医药卫生—内科学]