Fas／FasL信号在免疫系统中的作用  

Roles of Fas/FasL signals in immune system

作　　者：赵亮[1] 陈晓[1] 郭振红[1] 

机构地区：[1]第二军医大学附属长海医院学员大队本科生队,200433

出　　处：《国际免疫学杂志》2011年第1期49-52,共4页International Journal of Immunology

摘　　要：Fas／FasL通路是介导细胞凋亡的一条重要途径。近年来研究发现，它可以促进分泌炎症细胞因子，激发炎性反应，参与免疫豁免、免疫逃逸、肿瘤形成及转移等过程。此外，FasL还可以作为受体传递反向信号，促进细胞增殖，并参与一些自身免疫性疾病的发生。Fas/FasL mediates an important signal pathway cell apoptosis. Recent studies showed that it can stimulate the secretion of proinflammatory cytokines and induce inflammatory reaction. Inaddition, it also participates in a variety of biological activities such as immune privilege, immune escape and tumor formation and metastasis. FasL may also act as a receptor to deliver reverse signals, stimulating cell proliferation and paticipating in the development of some autoimmune diseases.

关 键 词：FAS/FASL 凋亡 炎症 反向信号 

分 类 号：R285.5[医药卫生—中药学]