中老年男性人群年龄与前列腺特异抗原水平的关系  

Relationship between age and prostate-specific antigen level in middle-aged and aged people in Beijing

作　　者：刘明[1] 王建业[1] 朱玲[2] 万钢[3] 赵艳燕[2] 马兰军[2] 

机构地区：[1]卫生部北京医院泌尿外科,100730 [2]卫生部北京医院体检中心,100730 [3]北京市地坛医院

出　　处：《中华老年医学杂志》2010年第12期999-1001,共3页Chinese Journal of Geriatrics

摘　　要：目的 了解中老年人群中血清前列腺特异抗原（PSA）随年龄分布的状况.方法 回顾性分析2006年11月至2008年11月北京医院体检中心常规体检资料,将进行PSA检查的男性按照年龄分组,分析不同年龄组中PSA的数值及分布状况.结果 11 557例男性入组,中位PSA值随年龄增长而上升,分别为40～49岁0.79μg/L,50～59岁0.85 μg/L,60～69岁1.20μg/L,70～79岁1.44 μg/L,80岁以上1.52μg/L.各组中PSA 4μg/L以上比例分别为1.3%、2.6%、8.8%、15.4%和14.4%.结论 北京市中老年人群中年龄与PSA水平呈正相关,PSA异常比例从60岁开始显著增加,人群中可能存在许多潜在的未被发现的前列腺癌患者.Objective To investigate the age distribution of serum prostate-specific antigen （PSA） in middle-aged and aged people in Beijing. Methods From November 2006 to November 2008, the data of men, who visited Beijing Hospital for routine health examination and received a measurement of serum PSA level, were collected and analyzed retrospectively. The eligible men were classified into various age groups over 10-years interval, and the PSA distributions were analyzed in the groups. Results A total of 11557 men were enrolled in this study. Within the entire cohort, the median PSA level was 0. 89 μg/L. The median PSA levels in each age group were as follows： 0. 79 μg/L in 40-49 yrs age group, 0.85 μg/L in 50-59 yrs age group, 1.20 μg/L in 60-69 yrs age group,1.44 μg/L in 70-79 yrs age group and 1.52 μg/L in more than 80 yrs age group. The serum PSA level gradually increased along with age. A rapid increase of PSA level began from 60 yrs age. The percentile of men with PSA 〉4 μg/L were 1.3%, 2.6%, 8.8%, 15.4% and 14.4% according to age category. Conclusions The PSA level is positively correlated with age in middle-aged and aged people in Beijing. Especially from 60 years of age, the percentile of men with abnormal PSA increases dramatically. Our results can guide clinicians to understand the population-based distribution of serum PSA and to screen prostate cancer.

关 键 词：前列腺特异抗原 年龄因素 

分 类 号：R686[医药卫生—骨科学]