原发性高血压患者血清中抗血管紧张素Ⅱ 1型受体自身抗体与血尿酸和肌酐的关系  

The Relationship Between Autoantibodies Against Angiotensin Ⅱ Receptor Type 1 and Uric Acid,Creatinine in Essential Hypertensives

作　　者：孙艳香[1] 廖玉华[2] 朱峰[2] 袁勇[1] 张励庭[1] 王敏[2] 

机构地区：[1]中山大学附属中山医院心内科,广东中山528400 [2]华中科技同济医学院附属协和医院心血管病研究所,湖北武汉430022

出　　处：《中华高血压杂志》2010年第11期1063-1066,共4页Chinese Journal of Hypertension

基　　金：国家自然科学基金(03600235)

摘　　要：目的研究原发性高血压患者血清中抗血管紧张素Ⅱ1型受体自身抗体(AT1-AAs)与血尿酸和肌酐的关系。方法收集原发性高血压患者血清样本344份,以酶联免疫吸附试验法检测AT1-AAs水平,以尿素酶法检测尿酸浓度,酶法检测肌酐、尿素氮浓度;按抗体稀释滴度分为抗体阴性组、1?40、1?80和1?160及以上组,比较各组患者血清肌酐及尿酸水平的差异。结果随抗体滴度升高,血肌酐水平逐渐上升,而血尿酸则逐渐下降[肌酐:(83.2±56.0),(85.3±48.9),(103.2±88.0),(144.7±136.1)μmol/L;尿酸:(344.2±118.6),(332.1±126.2),(332.2±127.6),(235.0±106.3)μmol/L;均P<0.05]。多分类有序变量logistic回归分析表明,影响AT1-AAs的因素为年龄、血肌酐和尿酸(OR值分别为1.031,2.374,0.881;均P<0.05)。结论原发性高血压患者血清中AT-AAs与血肌酐水平呈正相关;而与血尿酸水平呈负相关。Objective To study the relationship between autoantibodies against angiotensin Ⅱ receptor type 1（AT1-AAs）and uric acid,creatinine in essential hypertensives.Methods 344 patients with essential hypertension were selected.The AT-1-AAs in sera of patients were detected by ELISA.Serum uric acid,creatinine and urea nitrogen were detected by enzyme method.These patients were divided into 4 groups according to AT-1-AAs＇ titer：negative group,1∶40 group,1∶80 group,1∶160 and overtopping.Then observed the levels of uric acid and creatinine in different groups.Results The level of creatinine is gradually increasing and the level of uric acid decreasing as the increasing of AT-1-AAs concentration [creatinine（83.2±56.0）,（85.3±48.9）,（103.2±88.0）,（144.7±136.1）μmol/L;uric acid（344.2±118.6）,（332.1±126.2）,（332.2±127.6）,（235.0±106.3）μmol/L;all P0.05].Ordinal logistic regression analysis showed that age,the level of creatinine and uric acid were correlated with AT-1-AAs（respectively OR=1.031,2.374,0.881;all P0.05）.Conclusion The AT-1-AAs were positively related to the level of creatinine and negatively correlated with the level of uric acid.

关 键 词：高血压 自身抗体 血管紧张素Ⅱ1型受体 尿酸 肾功能 

分 类 号：R544.1[医药卫生—心血管疾病]