有氧运动合用人参皂苷对饮食性高脂血症小鼠脂质代谢的影响(英文)  

Effect of aerobic exercise and ginsenosides on lipid metabolism in diet-induced hyperlipidemia mice

作　　者：杨燕[1] 吴铁[1] 何康[1] 傅志刚[2] 

机构地区：[1]广东医学院药理教研室 [2]广东医学院基础医学部

出　　处：《中国药理学报》1999年第6期563-565,共3页Acta Pharmacologica Sinica

摘　　要：研究有氧运动及其合用人参茎叶皂苷（Ｇｉｎ）对饮食性高脂血症小鼠脂质代谢的影响。方法：通过喂养高胆固醇饲料２０天建立高脂血症模型，以无负重游泳作为有氧运动方式，观察有氧运动及其合用Ｇｉｎ时对高脂状态下小鼠的影响。结果：（１）高胆固醇饲料喂养２０天，小鼠血清ＴＣ，ＭＤＡ升高，ＨＤＬ－ｃ和ＳＯＤ降低，高脂血症模型建造成功，肝重量增加，有脂肪肝出现，胸腺重量减轻．（２）有氧运动降低ＴＣ，升高ＭＤＡ和ＨＤＬ－Ｃ，肝重量不减轻，脂肪肝存在．（３）有氧运动合用Ｇｉｎ时， ＴＣ， ＴＧ和 ＭＤＡ均降低（Ｐ＜ ０．０５）， ＨＤＬ－ｃ和ＳＯＤ显著升高（Ｐ＜０．０１），肝重量减轻和胸腺重量接近正常，脂肪肝消失．结论：单纯有氧运动可在一定程度上降低血脂，但不能很好调节脂质代谢，当有氧运动合用Ｇｉｎ时，其降脂调脂和抗氧化作用才更明显，并可能有一定的减慢机体衰老过程的作用。AIM: To study the effect of aerobic exercise and its combination with Gin (ginsenosides from stems and leaves of ginseng) on lipid metabolism in diet-induced hyperlipidemia mice. METHODS: The mouse hyperlipidemia model was set up by feeding high cholesterol diet. Unloaded swimming was designed to be a manner of aerobic exercise. The effects of aerobic exercise and its combination with Gin on total cholesterol (TC ), triglycerides (TG), high density lipoprotein cholesterol (HDL-c) in serum, malondialdehyde (MDA), and superoxide dismutase (SOD) in liver tissue were measured; the thymus and liver were weighed. RESULTS: (1) The mouse hyperlipidemia model was set up successfully: TC and MDA increased (P<0.05) but HDL-c and SOD decreased (P<0. 05); the liver weight increased and the thymus weight reduced; fatty liver was found; (2) aerobic exercise reduced TC but increased MDA and HDL-c in cholesterol-rich diet mice; the liver weight did not reduce, and fatty liver did not clear up; and (3) when aerobic exercise combined with Gin, TC and TG decreased markedly (P<0.01), and MDA also decreased (P<0.05); SOD and HDL-c increased markedly (P<0.01 ); the thymus weight increased and the liver weight decreased to normal level; fatty liver cleared up. CONCLUSION: Aerobic exercise could lower serum lipid to some extent but could not satisfactorily regulate lipid metabolism. When combined with Gin, aerobic exercise could better lower serum lipid, regulate lipid metabolism, promote antioxidation, and enhance immune activity.

关 键 词：运动 高脂血症 人参 糖苷 丙二醛 脂质 

分 类 号：R972.6[医药卫生—药品]