自噬在抗原加工呈递中作用的研究进展  

Research advance in the effect of autophagy on antigen processing and presentation

作　　者：李琼[1] 吴淑燕[1] 黄瑞[1] 

机构地区：[1]苏州大学基础医学与生物科学学院病原生物学系,苏州215123

出　　处：《微生物与感染》2010年第4期243-247,共5页Journal of Microbes and Infections

基　　金：国家自然科学基金(30972768)

摘　　要：细胞自噬在固有免疫和获得性免疫中发挥重要作用。自噬一方面通过溶酶体清除胞质内微生物,发挥天然抗感染免疫作用;另一方面可通过调节抗原加工、呈递,在获得性免疫反应中发挥效应。自噬除可参与并增强组织相容性复合物(MHC)Ⅱ类分子的抗原呈递外,在经典和非经典MHCⅠ类抗原呈递中也发挥辅助作用。Autophagy plays an important role in the innate and adaptive immune. On one hand,it acts as an innate immune response when eliminating microbes in cells via lysosome degradation; on the other hand,it acts effectively in adaptive immunity by regulating antigen processing and presentation. Autophagy is not only involved in and enhances major histocompatibility complex （MHC） II antigen presentation,but it also assists with classic and nonclassic MHC I antigen presentation.

关 键 词：自噬 抗原呈递 免疫反应 

分 类 号：R392.1[医药卫生—免疫学]