P物质及NK1-R在寻常型银屑病皮损中的表达  

Expression of substance P and its receptor in lesions of patients with psoriasis vulgaris

作　　者：梁淑雅[1,2] 杨海龙[3] 党林[1] 果玉珍[1] 

机构地区：[1]哈尔滨医科大学附属二院皮肤科,黑龙江哈尔滨150086 [2]青岛大学医学院附属医院皮肤科,青岛266003 [3]哈尔滨医科大学附属五院皮肤科,大庆163316

出　　处：《中国麻风皮肤病杂志》2010年第12期837-839,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的 : 检测P物质及P物质受体(NK1-R)在寻常型银屑病皮损中的表达。方法: 免疫组化法检测P物质及NK1-R在寻常型银屑病患者(16例进展期、10例稳定期)及15例正常人皮肤中的表达。结果 :P物质及NK1-R在寻常型银屑病皮损中呈高表达,(阳性表达率分别为96.15%、88.46%)与正常皮肤(阳性表达率分别为80%、66.67%)相比有显著性差异(均P<0.05);银屑病组进展期与稳定期患者P物质阳性表达率分别为93.75%、100%,NK1-R的阳性表达率分别为87.5%、90%,进展期与稳定期P物质及NK1-R表达相比差异无统计学意义(均P>0.05)。结论 :P物质与NK1-R可能共同参与了银屑病的发病。Objective： To determine the expression of substance P and its receptor in lesions of patients with psoriasis vulgaris. Methods： The expression of substance P and its receptor was detected by immunohistocbemistry in 16 active and 10 stable patients with psoriasis, and 15 nomlals. Results： Compared with normal controls, the expression of substance P and its receptor in lesions of patients with psoriasis vulgafis was significantly higher （ P 〈 0.05）, while there was no significant difference in the expression between active and stable patients （ P 〉 0.05 ）. Conclusion： Substance P and its receptor may play a role in the pathogenesis of psoriasis.

关 键 词：银屑病 P物质 NK1-R 免疫组织化学 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]