ε-己内酯与L-丙交酯共聚物降解性能及其生物相容性  

Biodegradability and biocompatibility of ε-caprolactone and L-lactide copolym

作　　者：高喜翔[1] 张建[1] 陈兵[1] 俞恒锡[1] 李建新[1] 张淑文[1] 孟艳[1] 韩健[2] 叶霖[2] 冯增国[2] 

机构地区：[1]首都医科大学宣武医院血管外科,北京市100053 [2]北京理工大学材料科学与工程学院,北京市100081

出　　处：《中国组织工程研究与临床康复》2010年第47期8791-8794,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金资助项目(30972944)~~

摘　　要：背景:ε-己内酯与L-丙交酯共聚物具有良好的力学性能,并且降解速率可调范围大,作为组织工程人工血管材料方面受到人们的青睐。目的:了解ε-己内酯与L-丙交酯共聚物(PCLA)的降解性能及生物相容性。方法:通过调节单体的投料比制备不同组成、不同相对分子质量的ε-己内酯/L-丙交酯共聚物,以脂肪酶溶液作为降解液研究共聚物的降解性能;并且通过体内种植实验研究其生物相容性。结果与结论:ε-己内酯与L-丙交酯投料摩尔比为75/25的ε-己内酯与L-丙交酯共聚物在降解过程中保持着较高的力学性能;并且组织相容性好,可用于制备组织工程人工血管。BACKGROUND：Copolymers of ε-caprolactone and L-lactide have good mechanical property,and regulable degradation rate.They become popular as a tissue engineered vascular graft.OBJECTIVE：To study the biodegradability and biocompatibility of ε-caprolactone and L-lactide copolymers.METHODS：A kind of ε-caprolactone/L-lactide copolymer with different compositions and molecular weights was prepared by varying the monomer molar ratios in feed.The biodegradability was studied in lipase solution（accelerated degradation）.The biocompatibility was also studied by implantation in vivo.RESULTS AND CONCLUSION：The ε-caprolactone/L-lactide copolymer at 75/25 molar ratio has a great mechanical property through the biodegradation,as well as high biocompatibility in vivo.It is suitable for the preparation of artificial blood vessel of tissue engineering.

关 键 词：共聚物 Ε-己内酯 L-丙交酯 生物可降解材料 生物相容性 组织工程人工血管 

分 类 号：R318[医药卫生—生物医学工程]