聚碳酸酯型聚氨酯的生物降解性  

Biodegradation of polycarbonate polyurethane

作　　者：庹新林[1] 夏维娟[1] 程晓非[2] 吴继功[2] 邹德威[2] 

机构地区：[1]清华大学材料科学与工程研究院化工系高分子研究所,北京市100084 [2]解放军第306医院,北京市100101

出　　处：《中国组织工程研究与临床康复》2010年第47期8831-8834,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家863计划课题资助(2006AA02Z4D4)~~

摘　　要：背景:不同聚氨酯材料的生物稳定性差异巨大,研究聚碳酸酯型聚氨酯的生物稳定性有利于评估其用于人工髓核外囊材料的可行性。目的:观察聚醚型聚氨酯和具有不同硬段含量的聚碳酸酯型聚氨酯材料的体外和体内降解性能。方法:用模拟环境进行聚氨酯的体外水解、氧化降解和酶解实验。分别置于37℃恒温的PBS缓冲液和"H2O2/CoCl2预氧化-Papain酶解体系"进行体外降解实验。将聚氨酯植入大耳白兔背部肌肉进行体内降解实验。结果与结论:聚碳酸酯型聚氨酯耐降解性远优于聚醚型聚氨酯,且材料硬段含量越大,耐降解性越强。所有研究结果表明聚碳酸酯型聚氨酯具有比聚醚型聚氨酯更加优越的生物稳定性,可用作较长期人工植入生物材料。BACKGROUND：Different polyurethanes vary in biostability.Study on the biostability of polycarbonate polyurethane（PCU）is important to determine the feasibility of polyurethane used as the external capsule of prosthetic disc nucleus pulposus.OBJECTIVE：To observe the in vitro and in vivo degradation properties of polyether polyurethane（PEU）and PCU with different hard segment contents.METHODS：The in vitro hydrolysis,oxidative degradation and enzymolysis experiments of the polyurethane were performed in simulated environment.The prepared PEU and PCU samples were dipped into PBS and ＂H2O2/CoCl2 preoxidation-Papain＂ systems for in vitro degradation study at 37 ℃,and implanted into the back muscle of white rabbits for in vivo degradation experiment.RESULTS AND CONCLUSION：The degradation of PCU is greatly better than PEU,with larger hard segment contents and stronger degradation resistance.PCU is much more biostable than PEU,it＇s more suitable for long-time biological implantation.

关 键 词：聚碳酸酯型聚氨酯 聚醚型聚氨酯 生物稳定性 降解性 生物材料 

分 类 号：R318[医药卫生—生物医学工程]