细胞黏附斑生物力学研究的现状  

Research progress of focal adhesions in cell biomechanics

作　　者：冯志远[1] 安晓莉[1] 张宝平[1] 马海冰[1] 王静[1] 刘斌[1] 

机构地区：[1]兰州大学口腔医学院,甘肃省兰州市730000

出　　处：《中国组织工程研究与临床康复》2010年第47期8843-8846,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：兰州大学青年交叉学科创新基金(lzujc200922);中国科学院兰州化学物理研究所固体润滑国家重点实验室开放项目(0808);教育部大学生创新性实验计划项目(LZUYX200625);中央高校基本业务费专项基金自由探索面上项目(lzujbky-2009-96)~~

摘　　要：背景:细胞黏附斑在其生物力学方向的研究虽然取得了很多进展,但仍然处于初期阶段,面临着理论模型与实验观察结果出现差异,一些模型缺乏实验依据,进一步优化模型设计等问题。目的:对近年国内外关于细胞黏附斑生物力学研究及其相关进展进行综述。方法:以"细胞黏附、黏附斑、黏附强度、细胞力学分子键、弹性界面"为中文关键词,以"cell adhesion,focal adhesions,adhesion strength,cell mechanics,molecular bond,flexible interface"为英文关键词。采用计算机检索中国知网数据库CNKI1995-01/2010-04、Pubmd数据库和Elsevier(ScienceDirect)数据库1975-01/2010-04有关细胞黏附斑生物力学的文献。排除重复研究。结果与结论:计算机初检得到109篇文献,排除因研究目的与本文无关及内容重复的研究64篇,共保留45篇文献做进一步分析。通过查阅国内外文献,国内外对黏附斑的研究主要集中在黏附斑的生物力学性质方面,重点从黏附斑与细胞骨架的相互作用、黏附斑的大小和黏附力的关系、细胞黏附界面弹性和黏附力的关系方面展开相关研究。随着细胞生物学、分子生物学和数学有限元建模分析方法的发展,为黏附斑的生物力学研究提供了新的空间。黏附斑的建模方法被进一步改进,更加接近生物学实验数据,有关黏附斑的力学问题也有了新的发现,黏附斑生物力学方向的研究有助于其他生物微观模型的建立和分析,有助于从力学角度解释细胞黏附的机制以及肿瘤细胞侵袭转移等一些关键问题。BACKGROUND：Focal adhesions have achieved many progresses in the biomechanical field,but the research is still at an early stage,facing the difference between theoretical model and experimental observations,some models lack experimental evidence and further optimizing.OBJECTIVE：To summarize recent research and related progress on focal adhesions biomechanics.METHODS：A computer-based online search of CNKI database from January 1995 to April 2010,PubMed database and Elsevier（ScienceDirect）database from January 1975 to April 2010,was performed with Keywords of ＂cell adhesion,focal adhesions,adhesion strength,cell mechanics,molecular bond,flexible interface＂ both in Chinese and English.Literatures concerning focal adhesions in cell biomechanics were included,repetitive research was excluded.RESULTS AND CONCLUSION：A total of 109 articles were screened out,64 of them were excluded due to unrelated study objective and repeated contents,finally 45 articles were involved in further analysis.At present,studies on focal adhesions mainly focus on the biomechanical properties of adhesion plaques,the interactions between focal adhesions and cytoskeleton,the size of focal adhesions and adhesion strength,flexible interface and adhesion.With the cell biology,molecular biology and mathematical modeling of the finite element analysis method develop,bio-mechanics study of adhesion plaque will have a new space.Focal adhesion modeling method is further improved and closer to the biological experimental data,the mechanical problems related to focal adhesion is also a new discovery,the focal adhesion biomechanical research can help to establish and analyze other biological micro-models,as well as to understand the mechanism underlying cell adhesion and invasion of tumor cells from the mechanical point of view.

关 键 词：细胞黏附 黏附斑 黏附力 细胞力学 分子键 弹性界面 

分 类 号：R318[医药卫生—生物医学工程]