人工韧带支架材料选择与腕关节韧带运动损伤的修复  

Selection of artificial ligament stent and repair of wrist ligament sports injury

作　　者：周海涛[1] 

机构地区：[1]北京联合大学生物化学工程学院体育教学部,北京市100023

出　　处：《中国组织工程研究与临床康复》2010年第47期8877-8880,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:对腕关节韧带损伤及人工韧带支架材料的选择进行探讨。方法:电子检索PubMed数据库及CNKI数据库,在标题和摘要中以"腕关节,韧带,损伤,支架"或"wrist Joint,ligament,injury,Stent"为检索词进行检索。选择与腕关节韧带损伤和治疗手段、材料学特点、生物相容性及其应用效果相关的文献,同一领域则选择近期发表或发表在国家核心期刊杂志的文献,最终纳入18篇。结果:人工合成可吸收性生物支架材料可作为韧带假体代替损伤的肌腱或韧带。LARS人工韧带模仿了人体韧带的解剖结构和生物力学特征,抗疲劳强度好,不易诱发炎症。自体移植肌腱韧带治疗动力型舟月骨间分离的效果较好,治疗静力型舟月骨间分离的效果差,生物型人工韧带的成品,与正常肌腱外观相似,质地柔韧,达到了预先设想的要求。结论:良好的生物相容性和抗疲劳强度,是选择韧带肌腱支架材料的必备条件,LARS人工韧带是一种理想的移植材料,但更适合于急性韧带损伤患者。自体移植肌腱韧带的供体选择较为困难。生物型人工韧带对腕关节韧带损伤的修复取得了较好的治疗效果。细胞和分子生物学技术以及基因疗法的运用,将成为腕关节韧带损伤的治疗与康复的新方向。OBJECTIVE：To investigate the wrist ligament injury and selection of ligament stent using artificial biomaterials.METHODS：The PubMed database and CNKI database were retrieved on computer,by screening Keywordsof ＂wrist joint,ligament,injury,stent＂ in English and in Chinese in the titles and abstracts.Articles related to wrist ligament injury and treatment,characteristics of materials science,biocompatibility and its application effect were included,those published recently or published in national core journals were preferred in the same field,ultimately 18 articles were involved.RESULTS：The synthetic absorbable scaffold materials may be used as a prosthetic ligament to replace the injured tendon or ligament.LARS artificial ligament imitates the anatomical structure and biomechanical characteristics of the human body,with good resistance to fatigue and not easy to induce inflammation.Treatment of tendon autograft ligament achieves excellent effect for dynamic scapholunate interosseous separation,but poor effect for static scapholunate separation,biological artificial ligament finished product is similar to normal tendon appearance,with flexible texture,reaches a pre-conceived requirement.CONCLUSION：The excellent biocompatibility and resistance to fatigue are essential for the selection of ligament tendon scaffolds,LARS artificial ligament is an ideal graft material,but more suitable for acute ligament injury patients.Ligament tendon autograft is difficult to select.Biological artificial ligament is effective to treat the wrist ligament injury.Cell and molecular biology techniques as well as the use of gene therapy will become a new direction in the treatment of wrist ligament injury and rehabilitation.

关 键 词：腕关节 韧带 损伤 支架 康复 生物材料 组织工程 

分 类 号：R318[医药卫生—生物医学工程]