复合骨形成蛋白和碱性成纤维细胞生长因子的双相陶瓷样生物活性骨修复指骨缺损  

Biphasic ceramic-like bioactive bone compounded by bone morphogenetic protein and basic fibroblast growth factor to repair finger bone defects

作　　者：王福科[1] 李彦林[2] 王国梁[2] 曹彬[2] 李晓林[2] 陈建明[2] 金耀峰[2] 王永年[2] 

机构地区：[1]昆明医学院第一附属医院头颈外科,云南省昆明市650032 [2]昆明医学院第一附属医院骨科,云南省昆明市650032

出　　处：《中国组织工程研究与临床康复》2010年第47期8885-8888,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:复合骨形成蛋白和碱性成纤维细胞生长因子的双相陶瓷样生物活性骨既有骨传导功能,又能诱导干细胞向成骨方向分化,已经成为用于骨缺损修复的理想骨移植替代材料之一。目的:初步观察复合骨形成蛋白和碱性成纤维细胞生长因子双相陶瓷样生物活性骨在临床修复指骨缺损的能力。方法:选取10例手指内生软骨瘤患者,平均年龄33岁。肿瘤大小为0.3cm×0.3cm×0.3cm^1.0cm×0.5cm×0.5cm;肿瘤均位于患指指骨,行肿瘤刮除术,瘤腔用双相陶瓷样生活性物骨填充,伤口常规缝合;术后观察伤口愈合情况,局部炎性反应,排斥反应,全身毒性,瘤腔愈合和患肢功能的恢复情况。结果与结论:术后无伤口感染,伤口均甲级愈合。局部炎性反应轻微,无排斥反应和全身毒性反应。术后全部获随访6个月,术后3个月可见新骨长入复合骨形成蛋白和碱性成纤维细胞生长因子双相陶瓷样生物活性骨填充区。手指在术后1个月可完成日常活动。提示复合骨形成蛋白和碱性成纤维细胞生长因子双相陶瓷样生物活性骨修复材料具有良好成骨性、生物安全性和相容性,可用于骨缺损的修复。BACKGROUND：Biphasic ceramic-like bioactive bone compounded bone morphogenetic protein（BMP）and basic fibroblast growth factor（bFGF）has bone conduction function,it can induce stem cells to differentiate into osteoblasts and have become one of ideal bone graft substitutes for repairing bone defects.OBJECTIVE：To explore the biphasic ceramic-like bioactive bone complex of BMP and bFGF in the clinical repair of bone phalanx defect.METHODS：Ten enchondroma patients,at a mean age of 33 years were selected.The tumor size was from 0.3 cm × 0.3 cm × 0.3 cm to 1.0 cm × 0.5 cm × 0.5 cm;tumors were located in the affected finger bone and performed tumor curettage,tumor cavities were stuffed with biphasic ceramic-like bioactive bone,followed by conventional wound suture;The postoperative wound healing,local inflammation,rejection,systemic toxicity,tumor cavity healing and recovery of limb function were observed after operation.RESULTS AND CONCLUSION：No postoperative wound infection,incisal opening healed well.Mild local inflammatory response was observed,with no rejection or systemic toxicity.All patients were followed up for 6 months,new bone grew into the complex BMP and BFGF biphasic ceramic-like bioactive bone filling areas at 3 months after surgery.Fingers could complete daily activities after 1 month.The complex BMP and BFGF biphasic ceramic-like bioactive bone has good osteogenesis,biological security and compatibility,can be used to repair bone defects.

关 键 词：双相陶瓷样生物活性骨 骨形成蛋白 碱性成纤维细胞生长因子 指骨缺损 临床应用 

分 类 号：R318[医药卫生—生物医学工程]