2型糖尿病及糖尿病肾病患者氧化型低密度脂蛋白检测的意义  

Significance of detecting oxidized low density lipoprotein level in patients with type 2 diabetes mellitus and diabetic nephropathy

作　　者：张国明[1] 胡礼仪[1] 韩洪波[2] 李志沭[1] 王满响[2] 

机构地区：[1]沭阳县人民医院检验科,江苏省223600 [2]沭阳县人民医院内分泌病科,江苏省223600

出　　处：《江苏医药》2010年第23期2766-2768,共3页Jiangsu Medical Journal

摘　　要：目的探讨2型糖尿病(T2DM)及合糖尿病合并肾病(DN)患者血浆氧化型低密度脂蛋白(ox-LDL)浓度变化及临床价值。方法根据尿清蛋白排泄率(UAER)将115例T2DM患者分为单纯糖尿病组(SDM组,46例),早期糖尿病肾病组(EDN组,40例)和临床糖尿病肾病组(CDN组,29例);另选30例健康体检者作为对照组(NC组)。采用酶联免疫吸附试验双抗体夹心法检测ox-LDL。结果 SDM组、EDN组、CDN组血浆ox-LDL、ox-LDL/低密度脂蛋白-胆固醇(LDL-C)、高敏C反应蛋白(hs-CRP)较NC组升高(P<0.05);随病情加重,升高更为明显。ox-LDL与hs-CRP高度相关(r=0.83,P<0.01),T2DM患者血浆ox-LDL水平随着尿清蛋白的增加而升高。结论 T2DM患者血浆ox-LDL水平明显升高,可作为DN早期敏感的诊断指标。Objective To investigate the concentration change and clinical significance of oxidized low density lipoprotein （ox-LDL） level in patients with type 2 diabetes mellitus（T2DM） and diabetic nephropathy（DN）.Methods According to urinary albumin excretion rate（UAER）,115 T2DM cases were divided into simple diabetic mellitus（SDM,46 cases）,early diabetic nephropathy（EDN,40 cases） and clinical diabetic nephropathy（CDN,29 cases）.Another 30 healthy persons were taken as the controls（group NC）.Blood level of ox-LDL was examined by ELISA with double antibody sandwich method.Results Compared with group NC,plasma levels of ox-LDL,ox-LDL/LDL-C and high sensitive C-reactive protein（hsCRP） in groups of SDM,EDN and CDN were significantly increased（P0.05）,which was more obvious as pathogenetic condition aggravated.ox-LDL was positively correlated with hsCRP（r=0.83,P0.01）.ox-LDL level increased as micro-albuminuria increased in T2DM patients.Conclusion The level of ox-LDL is increased in patients with T2DM,which may be taken as an early sensitive diagnostic marker for DN.

关 键 词：2型糖尿病 糖尿病肾病 氧化型低密度脂蛋白 尿清蛋白 

分 类 号：R589[医药卫生—内分泌]