足细胞的免疫功能  

Immune Functions of Podocytes

作　　者：张敏[1] 姜华军[1] 何艳[1] 刘建社[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院肾内科,武汉430022

出　　处：《中国细胞生物学学报》2010年第6期908-913,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.30900682)资助项目~~

摘　　要：足细胞位于肾小球滤过屏障的最外层。作为肾小球固有细胞之一,足细胞具有独特的细胞结构,在肾脏滤过中发挥着重要的生理功能。研究表明,足细胞与肾小球疾病之间关系密切,它不仅是肾小球疾病的被动受累者,而且可能主动地参与疾病的发生和发展。免疫介导的肾小球损伤是大多数肾小球疾病的发病机制,足细胞在其中的作用至今尚未阐明。既往足细胞作为滤过屏障的组成部分受到关注,而近年的研究结果表明足细胞与肾脏局部免疫密切相关,其可能通过免疫调节主动地参与肾小球疾病的发生。Podocytes are located at the most outer layer of the glomerular filtration barrier.As an intrinsic cell type of the glomeruli,podocytes have a special structure,and play an important role in the physiological process of kidney filtration.Some studies have shown that there is a close relationship between podocytes and glomerular diseases.Podocytes are not just passively involved in glomerular diseases.They may also actively participate in the occurrence and development of these diseases.At present it is accepted that immune mediated glomerular injuries are the causes of most glomerular diseases.However,the role of podocytes in this mechanism has not been fully illuminated.In the past,podocytes were emphasized a lot as a constitutive part of the filtration barrier,but recent results indicate that podocytes are closely related with local immunity in the kidneys,and may actively participate in the pathogenesis of glomerular diseases by immune regulation.

关 键 词：足细胞 免疫 肾小球肾炎 

分 类 号：Q2[生物学—细胞生物学]