Onconase研究与开发的最新进展  

Latest Advances in the Research and Development of Onconase

作　　者：田雪[1,2] 王庆诚 沈如凌 徐殿胜[1] 费俭 

机构地区：[1]华东理工大学生物反应器工程国家重点实验室,上海200237 [2]上海南方模式生物研究中心,上海201210

出　　处：《中国细胞生物学学报》2010年第6期927-934,共8页Chinese Journal of Cell Biology

摘　　要：Onconase是一种在北方豹蛙(Rana pipiens)卵母细胞和早期胚胎内存在的核糖核酸酶,是RNase A超家族中的一员,研究证实它在体内外对多种肿瘤均具显著杀伤作用。Onconase目前已经作为抗肿瘤药物上市,用于治疗恶性间皮瘤。Onconase结构独特,高度稳定。在临床上,Onconase具有副反应较轻,免疫原性低和不易产生耐药性等优点。因此Onconase的研究在学术上和医学应用上均具重要意义。本文综述了Onconase的结构特点、催化专一性、细胞毒性、体内外抗肿瘤活性及其临床应用的最新进展,并讨论了与其相关的一些重要问题。Onconase,a member of RNase A superfamily,is a ribonuclease originally purified from oocytes and early embryo of Nothern leopard frog（Rana pipiens）,which shows striking anti- tumor potential in vitro and in vivo.Onconase has been approved as an orphan drug applied for the treatment of malignant mesothelioma.Onconase has a unique structure and high stability.In clin- ics,it has shown mild side-effects,low immunogenicity and infrequent drug-resistance.Therefore,the research on Onconase possesses both important theoretical and clinically applied value.This paper reviews the latest advances of the studies on its structural characteristics,catalytic specificity, cytotoxicity,antitumor activity and clinical application.Meanwhile some important problems related to Onconase are discussed.

关 键 词：ONCONASE RNASE 抗肿瘤 免疫毒素 

分 类 号：Q55[生物学—生物化学]