强心甾类固醇作用于Na-K-ATP酶引起细胞内钙离子浓度改变的分子机制进展  

The Mechanism of Cardiac Glycosides Binding to Na-K-ATPase Influences the Intracellular Calcium:Research Advances

作　　者：曾一[1] 李娟 欧阳建 

机构地区：[1]东南大学医学院,南京210009 [2]南京市鼓楼医院血液科,南京210008

出　　处：《中国细胞生物学学报》2010年第6期951-954,共4页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.30971511)资助项目~~

摘　　要：Na-K-ATP酶(或称为钠泵)是一种广泛存在于真核细胞膜上的跨膜蛋白,近年来许多研究发现其不但有调节细胞内钠、钾离子浓度的功能,也可通过与不同蛋白相互作用发挥细胞信号传导作用。强心甾类固醇类药物(CTS)长久以来被用来治疗心脏疾病,近年来发现其与钠泵结合后可以激活细胞内一系列信号通路,其中很重要一点即是通过改变细胞内钙离子浓度从而调节细胞增殖、凋亡等。本文就CTS/钠泵通过与IP3R、Src、Na/Ca复合体相互作用影响细胞内钙离子浓度的改变作简要综述。The Na-K-ATPase,or sodium pump,is an ubiquitous membrane protein expresses on the eukaryote cells.Studies over the past years have given us insights about its versatile physiological functions.In addition to regulate intracellular sodium and potassium concentration,it is also an important signal transducer that interacts with proteins.The cardiac glycosides（CTS） have been used to treat heart disease for many years.Recent studies have revealed that this old group drugs which bind to the Na-K-ATPase,can activate multiple intracullar signal transduction pathways.One of the significant results of these activations is to change the concentration of intracellular calcium,which plays an important role for the regulation of cell proliferation and apoptosis in diverse cells.This minireview tries to illustrate the mechanism of how CTS/Na-K-ATPase complex influences intracellular calcium concentration through the interaction with IP3R,Src and Na~＋/Ca~＋ exchange.

关 键 词：Na-K-ATP酶(钠泵) 强心甾类固醇(CTS) 钙信号微结构域 肌醇三磷酸受体(IP3Rs) 钠钙交换体(NCX) 钠泵/Src复合物 

分 类 号：Q2[生物学—细胞生物学]