急性缺氧犬氰化钠中毒后心脏功能的变化  

Effects of NaCN Poisoning on Cardiac Function in Acute Hypoxia Dogs

作　　者：张晋煜[1,2] 唐禾[1] 蔡颖[1] 何悦[1] 董兆君[1] 

机构地区：[1]第三军医大学预防医学系防化教研室,重庆400038 [2]云南省肿瘤医院骨科,昆明650118

出　　处：《华北国防医药》2010年第6期511-513,共3页Medical Journal of Beijing Military Region

基　　金：军队"十一五"医学科研基金攻关项目(06G077)

摘　　要：目的研究氰化钠(NaCN)中毒对急性缺氧犬心脏功能的影响。方法将18只四川杂种家犬随机均分为常氧对照组和缺氧实验组。动物麻醉后行气管和左心室插管,常氧对照组吸入空气,缺氧实验组吸入氧-氮混合气体。术后1 h背部皮下注射NaCN3.6 mg/kg,记录中毒前即刻(0 min)及中毒后10、20、30、50 min各时间点心率、左心室收缩压峰值(LVSP)、左心室收缩压最大上升速率(+dp/dtmax),取静脉血测定乳酸脱氢酶(LDH)、肌酸激酶(CK)及肌酸激酶同工酶(CK-MB)的含量。结果常氧对照组NaCN中毒后,心率减慢、+dp/dtmax下降,LVSP和3种心肌酶含量升高。缺氧实验组上述指标变化趋势同常氧对照组,但变化时间提前、变化率增加。结论急性缺氧加重氰化物中毒对心脏功能的影响。Objective To study the effects of NaCN poisoning on cardiac function in acute hypoxia dogs.Methods 18 dogs were randomly divided into normoxic control group and hypoxic group.Endotracheal intubation and left ventricular catheterization were taken after anesthesia in both groups.The normoxic control group breathed the air while the hypoxia group inhaled oxygen-nitrogen mixture.One hour after the operation,NaCN was subcutaneously injected into the back of the dog in a dosage of 3.6 mg/kg.Heart rate（HR）,left ventricular systolic pressure（LVSP） and left ventricular pressure maximum upstroke velocity（＋dp/dtmax） were recorded at 0,10,20,30 and 50 min.Blood samples were drawn at the same time for Lactate Dehydrogenase（LDH）,creatine kinase（CK）,and creatine kinase-MB（CK-MB） detection.Results The HR slowed down and ＋dp/dtmax was decreased while the LVSP and the contents of three cardiac enzymes were increased after NaCN poisoning in normoxic control group.The same trend of these indicators was observed in the hypoxic group but the time of change was shorter and the rates of these changes also increased.Conclusion Acute hypoxia can strengthened cyanide intoxication in cardiac function.

关 键 词：缺氧 氰化钠 中毒 犬 心脏功能 

分 类 号：R992[医药卫生—毒理学] R821.4[医药卫生—药学]