辛夷挥发油纳米脂质体的制备及体外释放的研究  

Essential oil preparation of nano-liposomes and in vitro release study

作　　者：吴敏[1] 马博[1] 马碧涛[1] 王靖[2] 

机构地区：[1]上海交通大学医学院附属新华医院,上海200092 [2]教育部生物医用材料工程研究中心华东理工大学生物材料研究所,上海200237

出　　处：《中医药导报》2010年第12期79-82,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：上海市科委纳米专项课题(0852nm05500)

摘　　要：目的:制备辛夷挥发油纳米脂质体,并对其进行体外释药考察。方法:采用高压均质法制备辛夷挥发油纳米脂质体;用Franz扩散池考察其体外释药性质。结果:该制剂平均粒径81.1 nm,包封率为79.4%,载药量为47.5%;体外释药试验与辛夷挥发油相比,具有缓释效果。结论:本实验制备的辛夷挥发油纳米脂质体具有包封率高、粒径小的性质,体外能显著延缓药物释放,值得进一步研究。Objective： To prepare the volatile oil from nano-liposomes,and study its vitro release.Methods： Preparation ofvolatile oil homogeneous nano-liposomes with High pressure homogenization method;Investigat its vitro release characteristics with Franz diffusion cell.Results： The average size of the preparation was 81.1 nm,the encapsulation efficiency was 79.4%,drug loading was 47.5%;compared with volatile oil,in vitro release drug test has a sustained-release effect.Conclusion： The volatile oil prepared nano-liposomes with high entrapment efficiency,the nature of the small particle size,can significantly delay the in vitro drug release,it is worth further study.

关 键 词：辛夷 挥发油 纳米脂质体 体外释药 

分 类 号：R285.5[医药卫生—中药学]