一种生物材料聚(乳酸-蛋氨酸)的制备与表征  

Synthesis and Characterization of Biomaterial Poly(Lactic Acid-co-Methionine)

作　　者：杨利川[1] 叶瑞荣[1] 余世钦[1] 李景宁[1] 汪朝阳[1] 

机构地区：[1]华南师范大学化学与环境学院,广东广州510006

出　　处：《高分子材料科学与工程》2010年第12期129-132,共4页Polymer Materials Science & Engineering

基　　金：广东省自然科学基金资助项目(5300082);国家自然科学基金资助项目(20772035)

摘　　要：以功能分子蛋氨酸改性聚外消旋乳酸(PDLLA),采用直接熔融聚合法合成新型生物材料聚(乳酸-蛋氨酸)共聚物。用[η]、红外光谱(FT-IR)、核磁共振(1H-NMR)、凝胶渗透色谱(GPC)、差示扫描量热(DSC)及X射线衍射(XRD)等手段进行系统表征,探讨了催化剂种类和用量、熔融聚合反应时间和温度、不同投料比对共聚物合成的影响。当单体乳酸和蛋氨酸投料摩尔比为98/2时,在150℃、70Pa、催化剂SnCl2用量0.5%(质量分数,下同)的条件下熔融聚合10h,聚合物M-w可达7500。增加蛋氨酸投料量,-Mw逐渐降低,Tg均低于PDLLA,且均为无定型态,能满足药物缓释材料要求。Poly（D,L-lactic acid） （PDLLA） was modified by functional molecule methionine （Met）,and a novel biomaterial poly（lactic acid-co-methionine） was synthesized via direct melt polycondensation using D,L-lactic acid （LA） and Met as starting material. The copolymer was systematically characterized with intrinsic viscosity [η],Fourier transform infrared spectrum（FT-IR）,1H nuclear magnetic resonance spectrum（1H-NMR）,gel permeation in chromatography（GPC）,differential scanning calorimetry （DSC） and X-ray diffraction （XRD）. The influences of different synthetic conditions,including kinds and quantity of catalyst,time and temperature of melt copolycondensation,and different molar feed ratio on the polymer were discussed. Under the conditions of molar feed ratio of LA/Met 98/2,amount of catalyst SnCl2 0.5%,copolymerization temperature 150 ℃ and time 10 h,pressure 70 Pa,the copolymerization gave the polymer with maximum w 7500. Increasing the molar feed ratio of Met,w decreased gradually,all data of Tg were lower than that of homopolymer PDLLA and all copolymers were amorphous,which could meet the requirement for the application in drug delivery.

关 键 词：蛋氨酸 聚乳酸 熔融聚合 生物材料 药物缓释 

分 类 号：TB39[一般工业技术—材料科学与工程]