天然产物5,6,7,3′,4′-五甲氧基异黄酮的合成(英文)  

Synthesis of the Natural Product 5,6,7,3',4'-Pentamethoxyisoflavone

作　　者：任宛莉[1] 陈睿[2] 金叶[2] 张韬[2] 李洪启[2] 

机构地区：[1]宝鸡职业技术学院医学部,宝鸡721006 [2]东华大学化学化工与生物工程学院生态纺织教育部重点实验室,上海201620

出　　处：《天然产物研究与开发》2010年第6期956-960,共5页Natural Product Research and Development

基　　金：supported by Program for Changjiang Scholars and Innovative Research Team in University(No.IRT0526);Shanghai Natural Science Foundation(No.06ZR14001)

摘　　要：以3,4-二甲氧基苯乙酸和3,4,5-三甲氧基苯酚为原料,通过一条包括酯化反应、Fries重排、以及Vilsmeier-Haack反应等5步反应的路线合成了天然产物5,6,7,3′,4′-五甲氧基异黄酮。根据3,4,5-三甲氧基苯酚计算目标产物的总收率为76%,利用NMR及元素分析确证了化合物的结构。The natural product 5,6,7,3＇,4＇-pentamethoxyisoflavone was synthesized by a 5-step synthetic protocol including esterification,Fries transformation,and Vilsmeier-Haack reaction with 3,4-dimethoxyphenylacetic acid and 3,4,5-trimethoxyphenol as the starting materials.The overall yield of the target compound was 76% based on 3,4,5-trimethoxyphenol.The structure of the natural isoflavone 5,6,7,3＇,4＇-pentamethoxyisoflavone was confirmed by NMR and elemental analysis.

关 键 词：5 6 7 3′ 4′-五甲氧基异黄酮 3 4 5-三甲氧基苯酚 FRIES重排 Vilsmeier-Haack反应 合成 

分 类 号：Q946.91[生物学—植物学] R284.3[医药卫生—中药学]